Tetrahedron Letters

Electrochemical oxidation of 2, 2, 2-trifluoroethanol to trifluoroacetaldehyde 2, 2, 2-trifluoroethyl hemiacetal

K Shirai, O Onomura, T Maki, Y Matsumura

Index: Shirai, Kimihiro; Onomura, Osamu; Maki, Toshihide; Matsumura, Yoshihiro Tetrahedron Letters, 2000 , vol. 41, # 31 p. 5873 - 5876

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Citation Number: 11

Abstract

Electrochemical oxidation of 2, 2, 2-trifluoroethanol (1) gave trifluoroacetaldehyde 2, 2, 2- trifluoroethyl hemiacetal (2b), which was more reactive than commercially available trifluoroacetaldehyde ethyl hemiacetal (2a). The high reactivity of 2b was utilized, for example, for the facile synthesis of 1-furyl-2, 2, 2-trifluoroethanol (4) from furan.