2,2,2-Trifluoroethanol

Modify Date: 2026-07-01 10:47:54

2,2,2-Trifluoroethanol structure	Common Name	2,2,2-Trifluoroethanol
	CAS Number	75-89-8	Molecular Weight	100.040
	Density	1.393	Boiling Point	77-80 ºC
	Molecular Formula	C₂H₃F₃O	Melting Point	-45 ºC
	MSDS	Chinese USA	Flash Point	29 ºC
	Symbol	GHS02, GHS05, GHS06	Signal Word	Danger

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	2,2,2-trifluoroethanol
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.393
Boiling Point	77-80 ºC
Melting Point	-45 ºC
Molecular Formula	C₂H₃F₃O
Molecular Weight	100.040
Flash Point	29 ºC
Exact Mass	100.013596
PSA	20.23000
LogP	0.31
Vapour density	3.5 (vs air)
Vapour Pressure	77.3±0.2 mmHg at 25°C
Index of Refraction	1.2907
InChIKey	RHQDFWAXVIIEBN-UHFFFAOYSA-N
SMILES	OCC(F)(F)F
Stability	Stable. Flammable - note wide explosion limits. Moisture sensitive. Incompatible with strong oxidizing agents, strong acids, sodium, potassium.

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

2,2,2-Trifluoroethanol MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KM5250000

CHEMICAL NAME :: Ethanol, 2,2,2-trifluoro-

CAS REGISTRY NUMBER :: 75-89-8

BEILSTEIN REFERENCE NO. :: 1733203

LAST UPDATED :: 199710

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C2-H3-F3-O

MOLECULAR WEIGHT :: 100.05

WISWESSER LINE NOTATION :: Q1XFFF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,517,1986

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,517,1986

TYPE OF TEST :: Rinsed with water

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: LMF-84 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,607,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,607,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 71,84,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 366 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - changes in structure or function of salivary glands

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 15,83,1969

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2900 mg/m3/2H

TOXIC EFFECTS :: Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Behavioral - general anesthetic Lungs, Thorax, or Respiration - structural or functional change in trachea or bronchi

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 13(10),29,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 158 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: AMEBA7 Annales Medicinae Experimentalis et Biologiae Fenniae. (Helsinki, Finland) V.25-51, 1947-73. For publisher information, see MDBYAS. Volume(issue)/page/year: 46,242,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

REFERENCE :: AMEBA7 Annales Medicinae Experimentalis et Biologiae Fenniae. (Helsinki, Finland) V.25-51, 1947-73. For publisher information, see MDBYAS. Volume(issue)/page/year: 46,242,1968

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - hypermotility, diarrhea

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 15,83,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 350 mg/m3/4H/4W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Blood - normocytic anemia Related to Chronic Data - death

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 13(10),29,1969

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 350 mg/m3/4H/4W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Blood - normocytic anemia Related to Chronic Data - death

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 13(10),29,1969

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 1 gm/kg/5W-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Kidney, Ureter, Bladder - other changes Skin and Appendages - hair

REFERENCE :: TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 15,417,1987 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 100 ppm/6H

SEX/DURATION :: male 14 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 1,27,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 200 mg/kg

SEX/DURATION :: male 4 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 4,137,1984

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

DOSE :: 400 mg/m3/6H

SEX/DURATION :: male 8 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 18(Suppl 1),138,1983

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS02, GHS05, GHS06
Signal Word	Danger
Hazard Statements	H226-H301-H312-H315-H318-H331-H335
Precautionary Statements	P261-P280-P301 + P310-P305 + P351 + P338-P311
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xn:Harmful
Risk Phrases	R10;R20/21/22;R38;R41;R62
Safety Phrases	S26-S36-S39-S45-S36/37/39-S16
RIDADR	UN 1986 3/PG 3
WGK Germany	1
RTECS	KM5250000
Packaging Group	III
Hazard Class	3
HS Code	2905590090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 8
CAS#:75-88-7 f 133a CAS#:431-47-0 Methyl trifluor... CAS#:367-64-6 Acetic acid,2,2... CAS#:407-38-5 2,2,2-Trifluoro...
CAS#:164071-20-9 cyclohexylmethy... CAS#:383-67-5 Allyl trifluoro... CAS#:351-70-2 Benzyl trifluor... CAS#:1524-14-7 4-methylbenzyl ...
DownStream 10
CAS#:1065-05-0 2l5,4l5,6l5-1,3... CAS#:13053-90-2 (trifluoroethox... CAS#:55975-53-6 2-chloro-2,4,4,... CAS#:108195-09-1 phenyl-tris(2,2...
CAS#:1072855-75-4 6-((2,2,2-TRIFL... CAS#:1051372-09-8 3-BROMO-5-NITRO... CAS#:352-70-5 3-Fluorotoluene CAS#:80054-79-1 3-(2,2,2-triflu...
CAS#:372-20-3 3-Fluorophenol CAS#:372-18-9 1,3-Difluorobenzene

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2905590090
Summary	2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Cell-penetrating antimicrobial peptides - prospectives for targeting intracellular infections.

Pharm. Res. 32(5) , 1546-56, (2015)

To investigate the suitability of three antimicrobial peptides (AMPs) as cell-penetrating antimicrobial peptides.Cellular uptake of three AMPs (PK-12-KKP, SA-3 and TPk) and a cell-penetrating peptide ...

Quantification of serum IgG subclasses by use of subclass-specific tryptic peptides and liquid chromatography--tandem mass spectrometry.

Clin. Chem. 60(8) , 1080-8, (2014)

Measurement of IgG subclasses is a useful tool for investigation of humoral immune deficiency in the presence of total IgG within reference intervals and IgG4-related disease. Nephelometry has been th...

Metrological traceability in mass spectrometry-based targeted protein quantitation: a proof-of-principle study for serum apolipoproteins A-I and B100.

J. Proteomics 109 , 143-61, (2014)

In this study, we have followed up on previous liquid chromatography (LC) multiple reaction monitoring (MRM) mass spectrometry (MS) approaches for measurement of apolipoprotein (apo) A-I and apo B100 ...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Lipophilicity, logP of the compound by 19F NMR-based method
Source: ChEMBL
Target: N/A
External Id: CHEMBL4380721

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: qHTS assay to identify small molecule antagonists of the peroxisome proliferator-acti...
Source: 824
Target: N/A
External Id: PPARGV841

Name: qHTS assay to identify small molecule agonists of the TGF-beta/Smad signaling pathway...
Source: 824
Target: N/A
External Id: TGF788

Name: qHTS assay to identify small molecule antagonists of the TGF-beta/Smad signaling path...
Source: 824
Target: N/A
External Id: TGF602

Name: qHTS assay to test for compound auto fluorescence at 535 nm (green) in HEK293 cell fr...
Source: 824
Target: N/A
External Id: SPEC167MG

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: qHTS assay to identify small molecule agonists of the peroxisome proliferator-activat...
Source: 824
Target: N/A
External Id: PPARDV813

Name: qHTS assay to test for compound auto fluorescence at 590 nm (red) in HEK293 cell free...
Source: 824
Target: N/A
External Id: SPEC167MR

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Total 191, Current Page 1 of 20

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Trifluoroethyl alcohol

tfetoh

2,2,2-Trifluoroethanol

Ethanol,2,2,2-trifluoro

EINECS 200-913-6

Fluorinol 85

trifluoro ethanol

CF3CH2OH

1,1,1-trifluoroethanol

2,2,2-trifluoroethyl alcohol

MFCD00004672

2,2,2-trifluoro-ethanol

2,2,2-trifluoroethan-1-ol

Perfluoro-1,1-dihydroethanol

2,2,2-TRIFLUORO-1-P-TOLYL-ETHYLAMINE HYDROCHLORIDE

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the LogP of 2,2,2-trifluoroethanol?

A: LogP of 2,2,2-trifluoroethanol is 0.31.

Q: What English synonyms does 2,2,2-trifluoroethanol have?

A: English synonyms of 2,2,2-trifluoroethanol: Trifluoroethyl alcohol, tfetoh, 2,2,2-Trifluoroethanol, Ethanol,2,2,2-trifluoro, EINECS 200-913-6, Fluorinol 85, trifluoro ethanol, CF3CH2OH, 1,1,1-trifluoroethanol, 2,2,2-trifluoroethyl alcohol, MFCD00004672, 2,2,2-trifluoro-ethanol, 2,2,2-trifluoroethan-1-ol, Perfluoro-1,1-dihydroethanol, 2,2,2-TRIFLUORO-1-P-TOLYL-ETHYLAMINE HYDROCHLORIDE.

Q: What is the English name of 2,2,2-trifluoroethanol?

A: The English name of 2,2,2-trifluoroethanol is 2,2,2-trifluoroethanol.

Q: What are the downstream products of 2,2,2-trifluoroethanol?

A: Related downstream products(CAS) of 2,2,2-trifluoroethanol: 1065-05-0;13053-90-2;55975-53-6;108195-09-1;1072855-75-4;1051372-09-8;352-70-5;80054-79-1;372-20-3;372-18-9.

Q: What is the molecular weight of 2,2,2-trifluoroethanol?

A: Molecular weight of 2,2,2-trifluoroethanol is 100.040.

Q: What is the polar surface area (PSA) of 2,2,2-trifluoroethanol?

A: Polar surface area (PSA) of 2,2,2-trifluoroethanol is 20.23000.

Q: What are the upstream materials of 2,2,2-trifluoroethanol?

A: Related upstream materials(CAS) of 2,2,2-trifluoroethanol: 75-88-7;431-47-0;367-64-6;407-38-5;164071-20-9;383-67-5;351-70-2;1524-14-7.

Q: What is the molecular formula of 2,2,2-trifluoroethanol?

A: Molecular formula of 2,2,2-trifluoroethanol is C2H3F3O.

Q: What is the safety information for 2,2,2-trifluoroethanol?

A: Safety information for 2,2,2-trifluoroethanol: S26-S36-S39-S45-S36/37/39-S16.

Q: What is the boiling point of 2,2,2-trifluoroethanol?

A: Boiling point of 2,2,2-trifluoroethanol is 77-80 ºC.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2,2,2-Trifluoroethanol
Price: Check
Purity: 99.8%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,2,2-Trifluoroethanol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2,2,2-trifluoroethanol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Get all suppliers and price by the below link:

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2,2,2-Trifluoroethanol

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Articles64

2,2,2-TrifluoroethanolBioassay

Synonyms

2,2,2-Trifluoroethanol | FAQ

2,2,2-Trifluoroethanolfactory

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.