Structure–activity relationship of piperine and its synthetic analogues for their inhibitory potentials of rat hepatic microsomal constitutive and inducible cytochrome …

…, SC Taneja, KL Dhar, DS Jamwal, K Singh…

Index: Koul, Surrinder; Koul, Jawahir L.; Taneja, Subhash C.; Dhar, Kanaya L.; Jamwal, Deshvir S.; Singh, Kuldeep; Reen, Rashmeet K.; Singh, Jaswant Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 1 p. 251 - 268

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Citation Number: 69

Abstract

Inhibitors of drug metabolism have important implications in pharmaco-toxicology and agriculture. We have reported earlier that piperine, a major alkaloid of black and long peppers inhibits both constitutive and inducible cytochrome P450 (CYP)-dependent drug metabolising enzymes. In the present study, an attempt has been made to prepare several novel synthetic analogues so as to relate various modifications in the parent molecule to ...