Tetrahedron

Total synthesis of (S, S)-isodityrosine

ME Jung, LS Starkey

Index: Jung, Michael E.; Starkey, Laurie S. Tetrahedron, 1997 , vol. 53, # 26 p. 8815 - 8824

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Citation Number: 35

Abstract

The novel dimeric amino acid isodityrosine 1 has been synthesized by a route which uses a new method of diaryl ether preparation. Nucleophilic addition of a protected tyrosine to cyclohexenone oxide and the Pd (0)-catalyzed coupling of an aryl iodide with a protected iodoalanine derivative are the key steps in this synthesis. This represents one of the first efficient syntheses of this molecule beginning with two naturally-occurring amino acids as ...

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