Highly efficient, practical approach to natural taxol

JN Denis, AE Greene, D Guenard…

Index: Denis, Jean-Noel; Greene, Andrew E. Journal of the American Chemical Society, 1988 , vol. 110, # 17 p. 5917 - 5919

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Citation Number: 632

Abstract

Taxol (I)] is an exceptionally promising cancer chemotherapeutic agent with an unusually broad spectrum of potent antileukemic and tumor-inhibiting activity. 2 Taxol is active in vivo against P-388, P-1534, and L-1210 mouse leukemias, B-16 melanocarcinoma, Lewis lung carcinoma, sarcoma 180, and CX-I colon, LX-I lung, and MX-I breast~ enographs.'-~ The bark

~87%

Taxol semisynthesis: a highly enantio-and diastereoselective...

[Gennari, Cesare; Carcano, Michela; Donghi, Monica; Mongelli, Nicola; Vanotti, Ermes; Vulpetti, Anna Journal of Organic Chemistry, 1997 , vol. 62, # 14 p. 4746 - 4755]

Enantioselective total synthesis of (-)-taxol

[Kusama, Hiroyuki; Hara, Ryoma; Kawahara, Shigeru; Nishimori, Toshiyuki; Kashima, Hajime; Nakamura, Nobuhito; Morihira, Koichiro; Kuwajima, Isao Journal of the American Chemical Society, 2000 , vol. 122, # 16 p. 3811 - 3820]

Improved protection and esterification of a precursor of the...

[Commercon; Bezard; Bernard; Bourzat Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188]

Enantioselective total synthesis of (-)-taxol

[Journal of the American Chemical Society, , vol. 122, # 16 p. 3811 - 3820]