Synthesis of Tertiary sec??Alkylamines by the Addition of Grignard Reagents to N, N??Dialkylformamides Mediated by Ti (OiPr) 4 and Me3SiCl

…, U Welz??Biermann, V Chaplinski…

Index: Tomashenko, Olesya; Sokolov, Viktor; Tomashevskiy, Alexander; Buchholz, Herwig A.; Welz-Biermann, Urs; Chaplinski, Vladimir; De Meijere, Armin European Journal of Organic Chemistry, 2008 , # 30 p. 5107 - 5111

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Citation Number: 7

Abstract

Abstract A number of tertiary sec-alkylamines (22 examples, 29–80% yield) have been prepared according to a simple one-pot procedure by the addition of Grignard reagents to N, N-dialkylformamides in the presence of Ti (OiPr) 4 and Me 3 SiCl.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)