Tetrahedron letters

HMDS-promotedin situ amidation reactions of car☐ ylic acids and amines

WC Chou, MC Chou, YY Lu, SF Chen

Index: Chou, Wen-Chih; Chou, Ming-Chen; Lu, Yann-Yu; Chen, Shyh-Fong Tetrahedron Letters, 1999 , vol. 40, # 17 p. 3419 - 3422

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Citation Number: 11

Abstract

A number ofN-acylalkylenediamines were synthesized in high yields byin situ monoamidation of car☐ ylic acids with diamines. The amidation reactions were carried out simply by heating the substrates at 110° C for 5–24 h in the presence of HMDS. HMDS- promotedin situ amidation reactions are generally applicable to the synthesis ofN- acylalkylenediamines.