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e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Sodium Bis (trimethylsilyl) amide in the

JR Hwu, CH Hsu, FF Wong, CS Chung…

Index: Synthesis, , # 3 p. 329 - 332

Full Text: HTML

Citation Number: 13

Abstract

... Organic nitriles are traditionally synthesized from the cor- responding carboxylic acids by ultimate dehydration of the corresponding amide intermediates.3 The transforma- tions consist of two steps or more, and isolation of inter- mediates is required. ... 3; pp 617–620. ... SYNTHESIS ...

 Related Synthetic Route
Methyl anisate Structure

121-98-2

Methyl anisate

~26%

4-Hydroxybenzonitrile Structure

767-00-0

4-Hydroxybenzon...

4-Methoxybenzonitrile Structure

874-90-8

4-Methoxybenzon...

Learn More
Methyl anisate Structure

121-98-2

Methyl anisate

~83%

4-Hydroxybenzonitrile Structure

767-00-0

4-Hydroxybenzon...

Learn More
Ethylparaben Structure

120-47-8

Ethylparaben

~87%

4-Hydroxybenzonitrile Structure

767-00-0

4-Hydroxybenzon...

Learn More
Methyl 4-hydroxybenzoate Structure

99-76-3

Methyl 4-hydrox...

~92%

4-Hydroxybenzonitrile Structure

767-00-0

4-Hydroxybenzon...

Learn More
Methyl anisate Structure

121-98-2

Methyl anisate

~60%

4-Hydroxybenzonitrile Structure

767-00-0

4-Hydroxybenzon...

4-Methoxybenzonitrile Structure

874-90-8

4-Methoxybenzon...

Learn More
Methyl 2-methoxybenzoate Structure

606-45-1

Methyl 2-methox...

~22%

2-Cyanophenol Structure

611-20-1

2-Cyanophenol

2-Methoxybenzonitrile Structure

6609-56-9

2-Methoxybenzon...

Learn More
Methyl 3,4-dimethoxybenzoate Structure

2150-38-1

Methyl 3,4-dime...

~55%

4-Hydroxy-3-Methoxybenzonitrile Structure

4421-08-3

4-Hydroxy-3-Met...

3-Hydroxy-4-methoxybenzonitrile Structure

52805-46-6

3-Hydroxy-4-met...

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Methyl 3,4-dimethoxybenzoate Structure

2150-38-1

Methyl 3,4-dime...

~23%

3,4-Dihydroxybenzonitrile Structure

17345-61-8

3,4-Dihydroxybe...

4-Hydroxy-3-Methoxybenzonitrile Structure

4421-08-3

4-Hydroxy-3-Met...

Learn More
Methyl 3-Hydroxybenzoate Structure

19438-10-9

Methyl 3-Hydrox...

~85%

3-Cyanophenol Structure

873-62-1

3-Cyanophenol

Learn More
Methyl 2-methoxybenzoate Structure

606-45-1

Methyl 2-methox...

~59%

2-Cyanophenol Structure

611-20-1

2-Cyanophenol

2-Methoxybenzonitrile Structure

6609-56-9

2-Methoxybenzon...

Learn More
Related Articles: More...
Highly efficient Beckmann rearrangement and dehydration of o...

[Li, Dongmei; Shi, Feng; Guo, Shu; Deng, Youquan Tetrahedron Letters, 2005 , vol. 46, # 4 p. 671 - 674]
Transformation of aromatic bromides into aromatic nitriles v...

[Ishii, Genki; Moriyama, Katsuhiko; Togo, Hideo Tetrahedron Letters, 2011 , vol. 52, # 18 p. 2404 - 2406]
Facile transformation of esters to nitriles

[Suzuki, Yusuke; Moriyama, Katsuhiko; Togo, Hideo Tetrahedron, 2011 , vol. 67, # 41 p. 7956 - 7962]
Highly practical synthesis of nitriles and heterocycles from...

[Yin, Weiyu; Wang, Chengming; Huang, Yong Organic Letters, 2013 , vol. 15, # 8 p. 1850 - 1853]
Direct transformation of N, N-disubstituted amides and isopr...

[Suzuki, Yusuke; Yoshino, Takumi; Moriyama, Katsuhiko; Togo, Hideo Tetrahedron, 2011 , vol. 67, # 21 p. 3809 - 3814]

Detail Synthetic Route


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