Journal of medicinal chemistry

Cyclization-activated prodrugs: N-(substituted 2-hydroxyphenyl and 2-hydroxypropyl) carbamates based on ring-opened derivatives of active benzoxazolones and …

A Vigroux, M Bergon, C Zedde

Index: Vigroux, Alain; Bergon, Michel; Zedde, Chantal Journal of Medicinal Chemistry, 1995 , vol. 38, # 20 p. 3983 - 3994

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Citation Number: 49

Abstract

N4Substituted 2-hydroxyphenyl)-and N-(substituted 2-hydroxypropy1) carbamates based on masked active benzoxazolones (model A) and oxazolidinones (model B), respectively, were synthesized and evaluated as potential drug delivery systems. A series of alkyl and aryl N-(5- chloro-2-hydroxypheny1) carbamates 1 related to model A was prepared. These are open drugs of the skeletal muscle relaxant chlorzoxazone. The corresponding 4- ...