4-Acetamidophenol
Modify Date: 2026-07-12 19:15:58
4-Acetamidophenol structure
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Common Name | 4-Acetamidophenol | ||
|---|---|---|---|---|
| CAS Number | 103-90-2 | Molecular Weight | 151.163 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 387.8±25.0 °C at 760 mmHg | |
| Molecular Formula | C8H9NO2 | Melting Point | 168-172 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 188.4±23.2 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of 4-AcetamidophenolAcetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic drug. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | paracetamol |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic drug. |
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| Related Catalog | |
| Target |
COX-2:25.8 μM (IC50) COX-1:113.7 μM (IC50) Human Endogenous Metabolite |
| In Vitro | In vitro, acetaminophen elicites a 4.4-fold selectivity toward COX-2 inhibition (IC50 113.7 μM for COX-1; IC50 25.8 μM for COX-2). Following oral administration of the drug, maximal ex vivo inhibitions are 56% (COX-1) and 83% (COX-2). Acetaminophen plasma concentrations remaine above the in vitro IC50 for COX-2 for at least 5 h postadministration. Ex vivo IC50 values (COX-1: 105.2 μM; COX-2: 26.3 μM) of acetaminophen compared favorably with its in vitro IC50 values. In contrast to previous concepts, acetaminophen inhibited COX-2 by more than 80%, i.e., to a degree comparable to nonsteroidal antiinflammatory drugs (NSAIDs) and selective COX-2 inhibitors. However, a >95% COX-1 blockade relevant for suppression of platelet function is not achieved[1]. MTT assay shows that Acetaminophen (APAP) in a dose of 50 mM significantly (p<0.001) reduces cell viability to 61.5±6.65%. Interestingly, the significant (p<0.01) increase in cell viability to 79.7±2.47% is observed in the Acetaminophen/HV110 co-treated cells, compared to Acetaminophen treated cells[2]. |
| In Vivo | Administering Acetaminophen (250 mg/kg, orally) to the mice causes significant (p<0.001) liver damage and necrosis of cells as evidenced by the elevated serum hepatic enzymes alanine aminotransferase (ALT), aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (γGT) compared with normal group. Conversely, effects of pretreatment with different doses of citral (125, 250, and 500 mg/kg) exhibited a significant (p<0.05) decrease in serum activities of ALT (91.79%, 93.07%, and 95.61%, resp.), AST (93.40%, 91.89%, and 96.52%, resp.), ALP (39.29%, 37.07%, and 59.80%, resp.), and γGT (92.83%, 91.59%, and 93.0%, resp.), when compared to the Acetaminophen group. Similar results were found in pretreatment with SLM on the activity of ALT (95.90%), AST (95.03%), ALP (70.52%), and γGT (92.69%)[3]. |
| Cell Assay | Human hepatoma cell line HepG2 is cultured in low glucose DMEM supplemented with 10% fetal bovine serum (FBS), 100 U/mL Penicillin and 100 μg/mL Streptomycin and 2 mM l-glutamine. The cells are maintained in 75 cm2 flasks at 37°C in a humidified atmosphere containing 5% CO2 and split at 80% confluence every 5 days. Cells are seeded in 24-well plate (2×105 cells) and incubated at 37°C overnight followed by cells pretreatment with complete DMEM containing high glucose concentration in order to downregulate autophagy. After 6 h, cells are treated with different concentrations of postbiotics obtained from Lactobacillus fermentum BGHV110 strain (HV110) in order to select appropriate dose for further experiments. Postbiotic is dissolved in complete DMEM medium and added to the cells in specific final concentration. In all other experiments seeded cells are treated with 50 mM Acetaminophen alone or co-treated with 50 mM Acetaminophen and selected dose of lyophilized HV110. To analyze autophagic flux, simultaneously with treatments, cells are exposed to lysosomotropic agent Chloroquine at a concentration of 25 μM, to inhibit autophagosome-lysosome fusion[2]. |
| Animal Admin | Mice[3] Male Swiss mice (30-40 g) are used. The experimental animals are divided into six groups of five animals each. Firstly, each group receive orally during seven days the following treatment: Group I: the mice do not receive any treatment (normal). Group II: the mice receive citral vehicle (0.1% Tween 80 solution). Groups III-V: the mice are pretreated with citral at doses of 125, 250, and 500 mg/kg, respectively. Group VI: the mice are pretreated with the hepatoprotective standard drug Silymarin (SLM) (200 mg/kg). After this time, the animals fasted for 8 h and then receive oral Acetaminophen on the seventh day at a dose of 250 mg/kg in Groups II-VI. Group I orally receive saline that contained 0.1% Tween 80 solution (Acetaminophen vehicle). The stock solution is used as the first concentration of 50 mg/mL and after that is diluted in 0.1% Tween 80 solution to prepare the solutions of 25 and 12.5 mg/mL. After 12 h of Acetaminophen administration, serum samples and liver tissue are collected followed by biochemistry and histological analysis. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 387.8±25.0 °C at 760 mmHg |
| Melting Point | 168-172 °C(lit.) |
| Molecular Formula | C8H9NO2 |
| Molecular Weight | 151.163 |
| Flash Point | 188.4±23.2 °C |
| Exact Mass | 151.063324 |
| PSA | 49.33000 |
| LogP | 0.34 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.619 |
| InChIKey | RZVAJINKPMORJF-UHFFFAOYSA-N |
| SMILES | CC(=O)Nc1ccc(O)cc1 |
| Storage condition | Store at RT |
| Water Solubility | 14 g/L (20 ºC) |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H315-H317-H319 |
| Precautionary Statements | P280-P301 + P312 + P330-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin . R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment . R36/38:Irritating to eyes and skin . R40:Limited evidence of a carci |
| Safety Phrases | S26-S36-S61-S37/39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 1 |
| RTECS | AE4200000 |
| HS Code | 29242930 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 0 | |
|---|---|
| DownStream 10 | |
![N-[4-(quinolin-2-ylmethoxy)phenyl]acetamide structure](https://image.chemsrc.com/caspic/180/105326-63-4.png)
CAS#:105326-63-4![[4-[2-(4-azaniumylphenoxy)ethoxy]phenyl]azanium dichloride structure](https://image.chemsrc.com/caspic/273/109690-44-0.png)
CAS#:109690-44-0
CAS#:30824-21-6
CAS#:3273-78-7
CAS#:50375-15-0
CAS#:32113-41-0![Acetic acid,2-[4-(acetylamino)phenoxy] structure](https://image.chemsrc.com/caspic/474/39149-13-8.png)
CAS#:39149-13-8
CAS#:52980-20-8
CAS#:50700-49-7
CAS#:98555-06-7This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 29242930 |
|---|
This table lists relevant public references with title, journal and publication metadata for this compound.
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Characterization of a highly sensitive and selective novel trapping reagent, stable isotope labeled glutathione ethyl ester, for the detection of reactive metabolites.
J. Pharmacol. Toxicol. Methods 76 , 83-95, (2015) Glutathione (GSH) trapping assays are widely used to predict the post-marketing risk for idiosyncratic drug reactions (IDRs) in the pharmaceutical industry. Although several GSH derivatives have been ... |
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Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury.
Sci. Rep. 5 , 8521, (2015) Overdosing of the analgesic acetaminophen (APAP, paracetamol) is a major cause of acute liver injury. Whereas toxicity is initiated by hepatocyte necrosis, course of disease is regulated by mechanisms... |
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Simple and reliable HPLC method for the monitoring of methotrexate in osteosarcoma patients.
J. Chromatogr. Sci. 52(7) , 590-5, (2014) Methotrexate (MTX) is a dihydrofolate reductase inhibitor that is used for the treatment of tumors and autoimmune diseases. Several automated binding assays are used in clinical practice and numerous ... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| APAP |
| Calpol |
| NAPAP |
| p-acetaminophenol |
| Panadol |
| Tylenol |
| Exdol |
| 4-(Acetylamino)phenol |
| Fevor |
| N-(p-hydroxyphenyl)acetamide |
| Paracetamol |
| N-(4-Hydroxy-phenyl)-acetamide |
| Korum |
| 4-13-00-01091 (Beilstein Handbook Reference) |
| p-hydroxyacetanilide |
| G 1 |
| p-Acetylaminophenol |
| MFCD00002328 |
| Panex |
| QR DMV1 |
| N-(4-Hydroxyphenyl)acetamide |
| N-Acetyl-4-aminophenol |
| EINECS 203-157-5 |
| 4'-Hydroxyacetanilide |
| N-(4-Hydroxyphenyl)acetanilide |
| Acetaminophen |
| p-(Acetylamino)phenol |
| 4-Acetaminophenol |
| Dirox |
| 4-Acetamidophenol |
| Dypap |
| Hedex |
| N-Acetyl-p-aminophenol |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What are the uses of paracetamol? |
| A: Main uses of paracetamol: Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic drug. |
| Q: What is the InChIKey of paracetamol? |
| A: InChIKey of paracetamol is RZVAJINKPMORJF-UHFFFAOYSA-N. |
| Q: What is the molecular formula of paracetamol? |
| A: Molecular formula of paracetamol is C8H9NO2. |
| Q: What is the LogP of paracetamol? |
| A: LogP of paracetamol is 0.34. |
| Q: What is the boiling point of paracetamol? |
| A: Boiling point of paracetamol is 387.8±25.0 °C at 760 mmHg. |
| Q: What are the downstream products of paracetamol? |
| A: Related downstream products(CAS) of paracetamol: 105326-63-4;109690-44-0;30824-21-6;3273-78-7;50375-15-0;32113-41-0;39149-13-8;52980-20-8;50700-49-7;98555-06-7. |
| Q: What is the safety information for paracetamol? |
| A: Safety information for paracetamol: S26-S36-S61-S37/39. |
| Q: What are the storage conditions for paracetamol? |
| A: Storage conditions for paracetamol: Store at RT. |
| Q: What is the melting point of paracetamol? |
| A: Melting point of paracetamol is 168-172 °C(lit.). |
| Q: What is the molecular weight of paracetamol? |
| A: Molecular weight of paracetamol is 151.163. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |