Chemical Science

Divergent reaction pathways for phenol arylation by arynes: synthesis of helicenes and 2-arylphenols

T Truong, O Daugulis

Index: Truong, Thanh; Daugulis, Olafs Chemical Science, 2013 , vol. 4, # 1 p. 531 - 535

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Citation Number: 23

Abstract

Two reactions of phenols with arynes have been developed. If LiTMP base is employed, arynes generated from aryl chlorides react with phenols to form helicenes. o-Arylation of phenols can be achieved by employing tBuONa base in the presence of AgOAc. Direct arylation of binol was achieved leading to the shortest pathway to o, o′-diarylbinols.