Tetrahedron Letters

The use of zinc bromide for removal of dimethoxytrityl ethers from deoxynucleosides

MD Matteucci, MH Caruthers

Index: Matteucci, M. D.; Caruthers, M. H. Tetrahedron Letters, 1980 , vol. 21, p. 3243 - 3246

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Citation Number: 88

Abstract

Abstract Zinc Bromide has been observed to detritylate specifically 5′- trityldeoxydeoxynucleosides whereas 3′-trityl ethers are not cleaved. Of additional practical consideration and in contrast to protic acids, no depurination was observed with this reagent.

~97%

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