Bioorganic & medicinal chemistry

Structure–activity relationships for naturally occurring coumarins as β-secretase inhibitor

S Marumoto, M Miyazawa

Index: Marumoto, Shinsuke; Miyazawa, Mitsuo Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 2 p. 784 - 788

Full Text: HTML

Citation Number: 18

Abstract

The present study was demonstrated to evaluate the effects of naturally occurring coumarins (NOCs) including simple coumarins, furanocoumarins, and pyranocoumarins on the inhibition of β-secretase (BACE1) activity. Of 41 NOCs examined, some furanocoumarins inhibited BACE1 activity, but simple coumarins and pyranocoumarins did not affect. The most potent inhibitor was 5-geranyloxy-8-methoxypsoralen (31), which has an IC50 value ...

~90%

~36%

~44%

~67%

~63%

Butanones: Monoketones

[Koul, S. K.; Taneja, S. C.; Dhar, K. L. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 574 - 575]

Efficient synthesis of 6-prenylcoumarins; total syntheses of...

[Mali, Raghao S.; Sandhu, Paramjeet Kaur; Manekar-Tilve, Anita Journal of the Chemical Society, Chemical Communications, 1994 , # 3 p. 251 - 252]

New coumarins from Harbouria trachypleura: isolation and syn...

[Guz, Nathan R; Lorenz, Peter; Stermitz, Frank R. Tetrahedron Letters, 2001 , vol. 42, # 37 p. 6491 - 6494]

Butanones: Monoketones

[Koul, S. K.; Taneja, S. C.; Dhar, K. L. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, # 1-12 p. 574 - 575]