e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Development of 2, 4-Diaminopyrimidines as Antimalarials Based on Inhibition of the S108N and C59R+ S108N Mutants of Dihydrofolate Reductase from …

…, J Vanichtanankul…

Index: Bliss, Edward A.; Griffin, Roger J.; Stevens, Malcolm F. G. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2217 - 2228

Full Text: HTML

Citation Number: 85

Abstract

... Journal of Medicinal Chemistry. ... Road, Bangkok 10400, Thailand. J. Med. Chem. , 2002, 45 (6), pp 1244–1252. DOI: 10.1021/jm010131q. Publication Date (Web): February 9, 2002. Copyright © 2002 American Chemical Society. ...

6-ethyl-5-(4-fluoro-phenyl)-pyrimidine-2,4-diyldiamine Structure

6-ethyl-5-(4-fl...

~99%

2,4-diamino-5-(4-fluoro-3-nitrophenyl)-6-ethylpyrimidine Structure

2,4-diamino-5-(...

3-azidopyrimethamine Structure

3-azidopyrimethamine

~84%

pyrimethamine Structure

pyrimethamine Structure

~%

N'-[2-chloro-5-(2,4-diamino-6-ethylpyrimidin-5-yl)phenyl]-N,N-dimethylmethanimidamide Structure

N'-[2-chloro-5-...

2,4-Diamino-5-(3-amino-4-chloro-5-nitrophenyl)-6-ethylpyrimidine Structure

2,4-Diamino-5-(...

~%

N'-[2-chloro-5-(2,4-diamino-6-ethylpyrimidin-5-yl)phenyl]-N,N-dimethylmethanimidamide Structure

N'-[2-chloro-5-...

3-azidopyrimethamine Structure

3-azidopyrimethamine

~%

N'-[2-chloro-5-(2,4-diamino-6-ethylpyrimidin-5-yl)phenyl]-N,N-dimethylmethanimidamide Structure

N'-[2-chloro-5-...

N,N-Dimethylformamide dimethyl acetal Structure

N,N-Dimethylfor...

2,4-Pyrimidinediamine,5-(3-amino-4-chlorophenyl)-6-ethyl- Structure

2,4-Pyrimidined...

~%

N'-[2-chloro-5-(2,4-diamino-6-ethylpyrimidin-5-yl)phenyl]-N,N-dimethylmethanimidamide Structure

N'-[2-chloro-5-...

pyrimethamine Structure

~%

6-ethyl-5-(4-methoxyphenyl)pyrimidine-2,4-diamine Structure

6-ethyl-5-(4-me...

2,4-Diamino-5-(3-amino-4-chloro-5-nitrophenyl)-6-ethylpyrimidine Structure

2,4-Diamino-5-(...

~%

6-ethyl-5-(4-methoxyphenyl)pyrimidine-2,4-diamine Structure

6-ethyl-5-(4-me...

2,4-Pyrimidinediamine,5-(3-amino-4-chlorophenyl)-6-ethyl- Structure

2,4-Pyrimidined...

Acetyl chloride Structure

Acetyl chloride

~53%

N-[2-chloro-5-(2,4-diamino-6-ethylpyrimidin-5-yl)phenyl]acetamide Structure

N-[2-chloro-5-(...

2,4-Diamino-5-(3-amino-4-chloro-5-nitrophenyl)-6-ethylpyrimidine Structure

2,4-Diamino-5-(...

~%

N-[2-chloro-5-(2,4-diamino-6-ethylpyrimidin-5-yl)phenyl]acetamide Structure

N-[2-chloro-5-(...

pyrimethamine Structure

~%

N-[2-chloro-5-(2,4-diamino-6-ethylpyrimidin-5-yl)phenyl]acetamide Structure

N-[2-chloro-5-(...

3-azidopyrimethamine Structure

3-azidopyrimethamine

~%

N-[2-chloro-5-(2,4-diamino-6-ethylpyrimidin-5-yl)phenyl]acetamide Structure

N-[2-chloro-5-(...

pyrimethamine Structure

~96%

2,4-Diamino-5-(3-amino-4-chloro-5-nitrophenyl)-6-ethylpyrimidine Structure

2,4-Diamino-5-(...

2,4-DIAMINO-6-NITROQUINAZOLINE Structure

2,4-DIAMINO-6-N...

~91%

2,4,6-Quinazolinetriamine Structure

2,4,6-Quinazoli...

3-azidopyrimethamine Structure

3-azidopyrimethamine

~%

2,4-Pyrimidinediamine,5-(3-amino-4-chlorophenyl)-6-ethyl- Structure

2,4-Pyrimidined...

pyrimethamine Structure

~%

2,4-Pyrimidinediamine,5-(3-amino-4-chlorophenyl)-6-ethyl- Structure

2,4-Pyrimidined...