Development of Decarboxylative Coupling Processes for the Synthesis of Azomethines and Ketones

F Collet, B Song, F Rudolphi…

Index: Collet, Florence; Song, Bingrui; Rudolphi, Felix; Goossen, Lukas J. European Journal of Organic Chemistry, 2011 , # 32 p. 6486 - 6501

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Citation Number: 17

Abstract

Abstract A bimetallic catalyst system has been developed that allows the synthesis of azomethines by a one-pot three-component decarboxylative coupling, starting from simple, nontoxic precursors, ie potassium α-oxo carboxylates, aryl halides and primary amines. In the presence of 15 mol-% copper/phenanthroline and 1 mol-% Pd/dppf, a wide range of valuable imines is conveniently accessible in high yields at 100 C, an unprecedentedly ...