Correlation of hydrogen-bonding propensity and anticancer profile of tetrazole-tethered combretastatin analogues

…, RG Gonnade, MK Santra, E Hamel, TL Nguyen…

Index: Jedhe, Ganesh S.; Paul, Debasish; Gonnade, Rajesh G.; Santra, Manas K.; Hamel, Ernest; Nguyen, Tam Luong; Sanjayan, Gangadhar J. Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 16 p. 4680 - 4684

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Citation Number: 13

Abstract

Abstract A series of 1, 5-disubstituted tetrazole-tethered combretastatin analogues with extended hydrogen-bond donors at the ortho-positions of the aryl A and B rings were developed and evaluated for their antitubulin and antiproliferative activity. We wanted to test whether intramolecular hydrogen-bonding used as a conformational locking element in these analogues would improve their activity. The correlation of crystal structures with the ...