Anti-mycobacterial 4-hydroxy-3-phenylpyridin-2 (1H)-ones

G Dannhardt, W Meindl, BD Schober…

Index: Dannhardt, G; Meindl, W; Schober, B D; Kappe, T European Journal of Medicinal Chemistry, 1991 , vol. 26, # 6 p. 599 - 604

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Citation Number: 8

Abstract

Abstract 4-Hydroxy-3-phenylpyridin-2 (1H)-ones with different substituents either at N-1 or in the phenyl group were synthesized by reaction of ethyl β-aminocrotonates with dialkyl malonates or 'magic malonates'(2, 4, 6-trichlorophenyl malonates). The evaluation of these compounds on Mycobacterium tuberculosis H37Ra, Escherichia coli B and Staphylococcus aureus ATCC 25923 showed significant inhibitory effects on M tuberculosis (5g and 5s, ...