Curcuminoid analogs inhibit nitric oxide production from LPS-activated microglial cells

…, C Tocharus, C Changtam, A Suksamrarn

Index: Tocharus, Jiraporn; Jamsuwan, Sataporn; Tocharus, Chainarong; Changtam, Chatchawan; Suksamrarn, Apichart Journal of Natural Medicines, 2012 , vol. 66, # 2 p. 400 - 405

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Citation Number: 16

Abstract

Abstract The chemically modified analogs, the demethylated analogs 4–6, the tetrahydro analogs 7–9 and the hexahydro analogs 10–12, of curcumin (1), demethoxycurcumin (2) and bisdemethoxycurcumin (3) were evaluated for their inhibitory activity on lipopolysaccharide activated nitric oxide (NO) production in HAPI microglial cells. Di-O- demethylcurcumin (5) and O-demethyldemethoxycurcumin (6) are the two most potent ...

~17%

~66%

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