Synthesis

Regioselective synthesis of 1, 3, 5-substituted pyrazoles from acetylenic ketones and hydrazines

BC Bishop, KMJ Brands, AD Gibb, DJ Kennedy

Index: Bishop, Brian C.; Brands, Karel M. J.; Gibb, Andrew D.; Kennedy, Derek J. Synthesis, 2004 , # 1 p. 43 - 52

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Citation Number: 91

Abstract

Abstract The synthesis of diversely substituted 1, 3, 5-substituted pyrazoles from the reaction of acetylenic ketones with substituted hydrazines is reported. The reactions were shown to be highly regioselective regardless of the nature of the substituents in the substrates and afforded essentially single pyrazole isomers in excellent yields.

~82%

~83%

~84%

~0%

~0%

~80%

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