Tetrahedron

Efficient synthesis of carbonyl compounds: oxidation of azides and alcohols catalyzed by vanadium pentoxide in water using tert-butylhydroperoxide

K Alagiri, KR Prabhu

Index: Alagiri, Kaliyamoorthy; Prabhu, Kandikere Ramaiah Tetrahedron, 2011 , vol. 67, # 44 p. 8544 - 8551

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Citation Number: 37

Abstract

Catalytic amount of vanadium reagent with tert-butylhydroperoxide as the oxidant was found to be an excellent oxidizing agent in aqueous medium. Vanadium pentoxide with aq tert- butylhydroperoxide readily oxidizes primary benzylic azides to the corresponding acids and secondary benzylic azides to the corresponding ketones in excellent yields. Further, vanadium pentoxide and aq tert-butylhydroperoxide combination turned out to be an ...