Bioorganic & medicinal chemistry letters

Design and synthesis of dimethylaminomethyl-substituted curcumin derivatives/analogues: potent antitumor and antioxidant activity, improved stability and aqueous …

X Fang, L Fang, S Gou, L Cheng

Index: Fang, Xubin; Fang, Lei; Gou, Shaohua; Cheng, Lin Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1297 - 1301

Full Text: HTML

Citation Number: 27

Abstract

A series of dimethylaminomethyl-substituted curcumin derivatives/analogues were designed and synthesized. All compounds effectively inhibited HepG2, SGC-7901, A549 and HCT- 116 tumor cell lines proliferation in MTT assay. Particularly, compounds 2a and 3d showed much better activity than curcumin against all of the four tumor cell lines. Antioxidant test revealed that these compounds had higher free radical scavenging activity than curcumin ...