Tetrahedron letters

An efficient method for the synthesis of substituted TosMIC precursors

J Sisko, M Mellinger, PW Sheldrake, NH Baine

Index: Sisko, Joseph; Mellinger, Mark; Sheldrake, Peter W.; Baine, Neil H. Tetrahedron Letters, 1996 , vol. 37, # 45 p. 8113 - 8116

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Citation Number: 66

Abstract

Substituted tosylmethyl isocyanides (TosMICs) are useful reagents for which no general method of preparation is available. We describe here a high-yielding method for the synthesis of substituted tosylmethyl formamides, which are readily converted to the corresponding isocyanides.