N 6-Alkyladenosines: Synthesis and evaluation of in vitro anticancer activity

…, S Casati, E Baldoli, JAM Maier, P Ciuffreda

Index: Ottria, Roberta; Casati, Silvana; Baldoli, Erika; Maier, Jeanette A.M.; Ciuffreda, Pierangela Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 23 p. 8396 - 8402

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Citation Number: 22

Abstract

A series of adenosine analogues differently substituted in N6-position were synthesized to continue our studies on the relationships between structure and biological activity of iPA. The structures of the compounds were confirmed by standard studies of 1H NMR, MS and elemental analysis. These molecules were then evaluated for their anti-proliferative activity on bladder cancer cells. We found that some of these compounds possess anti- ...