Russian Journal of Organic Chemistry

Reduction of 2-amino-3-and-5-nitropyridine derivatives with hydrazine hydrate

NN Smolyar, YM Yutilov

Index: Smolyar; Yutilov Russian Journal of Organic Chemistry, 2009 , vol. 45, # 1 p. 115 - 118

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Citation Number: 3

Abstract

Abstract The reactions of 2-amino-3-nitropyridine and 2-amino-5-nitropyridine with hydrazine hydrate resulted in elimination of the amino group and reduction of the nitro group with formation of 3-aminopyridine. A probable reaction mechanism involves addition of hydrazine hydrate at the NC 2 bond, followed by elimination of ammonia and reduction of the nitro group to amino. 2-Amino-4-methyl-3-nitropyridine and 2-amino-5-methyl-3- ...