Mapping the Landscape of Potentially Primordial Informational Oligomers: Oligodipeptides Tagged with 2, 4??Disubstituted 5??Aminopyrimidines as Recognition …

…, R Krishnamurthy, A Eschenmoser

Index: Mittapalli, Gopi Kumar; Osornio, Yazmin M.; Guerrero, Miguel A.; Reddy, Kondreddi Ravinder; Krishnamurthy, Ramanarayanan; Eschenmoser, Albert Angewandte Chemie - International Edition, 2007 , vol. 46, # 14 p. 2478 - 2484

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Citation Number: 66

Abstract

The canonical purine bases of the natural nucleic acids occupy a central position in the chemist s reasoning of the problem of life s origin. Their formation from aqueous ammonium cyanide under a variety of potentially prebiotic conditions [2] and the fundamental function these bases fulfill as recognition elements in contemporary life s genetic system constitute facts deemed to be intimately related to each other. The generational relationship the ...