The ruthenium-catalyzed reduction and reductive N-alkylation of secondary amides with hydrosilanes: Practical synthesis of secondary and tertiary amines by …

…, T Ishida, Y Motoyama, H Nagashima

Index: Hanada, Shiori; Ishida, Toshiki; Motoyama, Yukihiro; Nagashima, Hideo Journal of Organic Chemistry, 2007 , vol. 72, # 20 p. 7551 - 7559

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Citation Number: 95

Abstract

A triruthenium cluster,(μ3, η2, η3, η5-acenaphthylene) Ru3 (CO) 7 (1) catalyzes the reaction of secondary amides with hydrosilanes, yielding a mixture of secondary amines, tertiary amines, and silyl enamines. Production of secondary amines with complete selectivity is achieved by the use of higher concentration of the catalyst (3 mol%) and the use of bifunctional hydrosilanes such as 1, 1, 3, 3-tetramethyldisiloxane. Acidic workup of the ...