Process research and development for the kilogram manufacture of the SRC kinase inhibitor AZD0530

…, L Powell, PS Siedlecki, J Baum, R Chubb…

Index: Ford, J. Gair; Pointon, Simon M.; Powell, Lyn; Siedlecki, Paul S.; Baum, John; Chubb, Richard; Fieldhouse, Robin; Muxworthy, James; Nivlet, Alex; Stenson, Rachel; Warwick, Eleanor Organic Process Research and Development, 2010 , vol. 14, # 5 p. 1078 - 1087

Full Text: HTML

Citation Number: 9

Abstract

Process research and development of a synthetic route towards a novel SRC kinase inhibitor is described. The Medicinal Chemistry route was very long and suffered from extensive use of chlorinated solvents and chromatography. A number of steps in the Medicinal Chemistry route were also unattractive for large-scale use for a variety of reasons. The route was modified to produce a shorter synthetic scheme that started from more ...