e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Behavioral approach to nondyskinetic dopamine antagonists: identification of seroquel

…, BM Migler, CJ Ohnmacht, AL Needles…

Index: Dostert; Langlois; Guerret; et al. European Journal of Medicinal Chemistry, 1980 , vol. 15, # 3 p. 199 - 205

Full Text: HTML

Citation Number: 40

Abstract

... Journal of Medicinal Chemistry. ... Departments of Medicinal Chemistry, Pharmacology, and Drug Disposition and Metabolism, AstraZeneca Pharmaceuticals LP, PO Box 15437, Wilmington, Delaware 19850-5437. J. Med. Chem. ...

1-Propanone,1-(1H-benzimidazol-2-yl)-2-methyl-(9CI) Structure

1-Propanone,1-(...

~%

4,5-Dihydro-1-(1-methylethyl)-1,4-epoxy-1H,3H-(1,4)oxazepino(4,3-a)ben zimidazole Structure

4,5-Dihydro-1-(...

Methanone,1H-benzimidazol-2-ylphenyl- Structure

Methanone,1H-be...

~%

1,4-Epithio-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-1-ph enyl- Structure

1,4-Epithio-1H,...

2-(2-phenyl-1,3-dioxolan-2-yl)-1H-benzimidazole Structure

2-(2-phenyl-1,3...

~%

1,4-Epithio-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-1-ph enyl- Structure

1,4-Epithio-1H,...

1-(oxiran-2-ylmethyl)-2-(2-phenyl-1,3-dioxolan-2-yl)benzimidazole Structure

1-(oxiran-2-ylm...

~%

1,4-Epithio-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-1-ph enyl- Structure

1,4-Epithio-1H,...

2-(2-phenyl-1,3-dioxolan-2-yl)-1-(thiiran-2-ylmethyl)-1H-benzo[d]imidazole Structure

2-(2-phenyl-1,3...

~22%

1,4-Epithio-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-1-ph enyl- Structure

1,4-Epithio-1H,...

N/A Structure

~%

brn 5651178 Structure

N/A Structure

~%

brn 5651178 Structure

[1-(2,2-Dimethyl-[1,3]dioxolan-4-ylmethyl)-5-nitro-1H-benzoimidazol-2-yl]-phenyl-methanol Structure

[1-(2,2-Dimethy...

~%

brn 5651178 Structure

2,4-Dinitrochlorobenzene Structure

2,4-Dinitrochlo...

~%

brn 5651178 Structure

(1-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-5-nitro-1H-benzo[d]imidazol-2-yl)(phenyl)methanone Structure

(1-((2,2-dimeth...

~%

brn 5651178 Structure

1-(2-benzyloxyphenyl)-4,5-dihydro-1,4-epoxy-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole Structure

1-(2-benzyloxyp...

~15%

brn 5608352 Structure

1H-benzimidazol-2-yl-(2-methylphenyl)methanone Structure

1H-benzimidazol...

~%

1,4-Epoxy-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-1-(2-m ethylphenyl)- Structure

1,4-Epoxy-1H,3H...

Methanone,1H-benzimidazol-2-ylphenyl- Structure

Methanone,1H-be...

~%

1,4-Epoxy-1H-(1,4)oxazocino(4,3-a)benzimidazole, 3,4,5,6-tetrahydro-1- phenyl- Structure

1,4-Epoxy-1H-(1...

(1H-benzo[d]imidazol-2-yl)(3-fluorophenyl)methanone Structure

(1H-benzo[d]imi...

~%

4,5-Dihydro-1-(3-fluorophenyl)-1,4-epoxy-1H,3H-(1,4)oxazepino(4,3-a)be nzimidazole Structure

4,5-Dihydro-1-(...

N/A Structure

~%

1,4-Epoxy-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-1-cycl ohexyl- Structure

1,4-Epoxy-1H,3H...

Methanone,1H-benzimidazol-2-ylphenyl- Structure

Methanone,1H-be...

~%

1,4-Epoxy-1H,3H-(1,4)oxazonino(4,3-a)benzimidazole, 4,5,6,7-tetrahydro-1-phenyl- Structure

1,4-Epoxy-1H,3H...

N/A Structure

~%

1,4-Epoxy-1H,3H-(1,4)oxazonino(4,3-a)benzimidazole, 4,5,6,7-tetrahydro-1-phenyl- Structure

1,4-Epoxy-1H,3H...

Methanone,1H-benzimidazol-2-ylphenyl- Structure

Methanone,1H-be...

~%

brn 5603142 Structure

Methanone,1H-benzimidazol-2-ylphenyl- Structure

Methanone,1H-be...

~%

1,4-(Epoxymethanol)-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihy dro-1-phenyl- Structure

1,4-(Epoxymetha...

Methanone,1H-benzimidazol-2-ylphenyl- Structure

Methanone,1H-be...

~%

1-(oxiran-2-ylmethyl)-2-(2-phenyl-1,3-dioxolan-2-yl)benzimidazole Structure

1-(oxiran-2-ylm...

2-Acetylbenzimidazole Structure

2-Acetylbenzimi...

~%

brn 1122749 Structure

1-(1H-benzo[d]imidazol-2-yl)-2,2-dimethylpropan-1-one Structure

1-(1H-benzo[d]i...

~%

1,4-Epoxy-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-1-(1,1-dimethylethyl)- Structure

1,4-Epoxy-1H,3H...

1-(1H-benzimidazol-2-yl)propan-1-ol Structure

1-(1H-benzimida...

~%

1,4-Epoxy-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-1-ethy l- Structure

1,4-Epoxy-1H,3H...

1-Propanone,1-(1H-benzimidazol-2-yl)-(9CI) Structure

1-Propanone,1-(...

~%

1,4-Epoxy-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-1-ethy l- Structure

1,4-Epoxy-1H,3H...

1-Propanone,1-(1H-benzimidazol-2-yl)-(9CI) Structure

1-Propanone,1-(...

(2,2-Dimethyl-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate Structure

(2,2-Dimethyl-1...

~%

1,4-Epoxy-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-1-ethy l- Structure

1,4-Epoxy-1H,3H...

benzimidazol-2-yl 2-thienyl ketone Structure

benzimidazol-2-...

~%

1,4-Epoxy-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-1-(2-t hienyl)- Structure

1,4-Epoxy-1H,3H...

(1H-benzo[d]imidazol-2-yl)(2-methoxyphenyl)methanone Structure

(1H-benzo[d]imi...

~%

brn 5620695 Structure

(1H-benzo[d]imidazol-2-yl)(2-fluorophenyl)methanone Structure

(1H-benzo[d]imi...

~%

brn 5608350 Structure

2-benzoylimidazole Structure

2-benzoylimidazole

~%

6,7-Dihydro-9-phenyl-6,9-epoxy-5H,9H-imidazo(2,1-c)(1,4)oxazepine Structure

6,7-Dihydro-9-p...

Methanol Structure

1-(2-hydroxyethyl)-2-benzoylbenzimidazole Structure

1-(2-hydroxyeth...

~74%

1-methoxy-1-phenyl-3,4-dihydro-[1,4]oxazino[4,3-a]benzimidazole Structure

1-methoxy-1-phe...

(1H-benzo[d]imidazol-2-yl)(3-chlorophenyl)methanone Structure

(1H-benzo[d]imi...

~%

1,4-Epoxy-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-1-(3-c hlorophenyl)- Structure

1,4-Epoxy-1H,3H...

Methanone, 1H-benzimidazol-2-yl(3-methoxyphenyl)- Structure

Methanone, 1H-b...

~%

1,4-Epoxy-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-1-(3-m ethoxyphenyl)- Structure

1,4-Epoxy-1H,3H...

2,4-Difluoronitrobenzene Structure

2,4-Difluoronit...

~%

8-fluoro-4,5-dihydro-1-phenyl-1,4-epoxy-1H,3H-<1,4> oxazepino <4,3-a> benzimidazole Structure

8-fluoro-4,5-di...

N-((2,2-dimethyl-1,3-dioxolan-4-yl)methyl)-5-fluoro-2-nitroaniline Structure

N-((2,2-dimethy...

~%

8-fluoro-4,5-dihydro-1-phenyl-1,4-epoxy-1H,3H-<1,4> oxazepino <4,3-a> benzimidazole Structure

8-fluoro-4,5-di...

Methanone,1H-benzimidazol-2-ylphenyl- Structure

Methanone,1H-be...

~%

1-methoxy-1-phenyl-4,5-dihydro-3H-[1,4]oxazepino[4,3-a]benzimidazole Structure

1-methoxy-1-phe...

phenyl(1-(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)-1H-benzo[d]imidazol-2-yl)methanone Structure

phenyl(1-(3-((t...

~%

1-methoxy-1-phenyl-4,5-dihydro-3H-[1,4]oxazepino[4,3-a]benzimidazole Structure

1-methoxy-1-phe...

Methanol Structure

3-(2-benzoyl-benzimidazol-1-yl)-propanol Structure

3-(2-benzoyl-be...

~19%

1-methoxy-1-phenyl-4,5-dihydro-3H-[1,4]oxazepino[4,3-a]benzimidazole Structure

1-methoxy-1-phe...

Methanone,1H-benzimidazol-2-yl(4-chlorophenyl)- Structure

Methanone,1H-be...

~%

brn 1154636 Structure

1H-benzimidazol-2-yl-(4-fluorophenyl)methanone Structure

1H-benzimidazol...

~47%

brn 1154635 Structure

1H-benzimidazol-2-yl-(3-methylphenyl)methanone Structure

1H-benzimidazol...

~%

1,4-Epoxy-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-1-(3-m ethylphenyl)- Structure

1,4-Epoxy-1H,3H...

1-(1H-benzo[d]imidazol-2-yl)heptan-1-one Structure

1-(1H-benzo[d]i...

~%

1,4-Epoxy-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-1-hexy l- Structure

1,4-Epoxy-1H,3H...

1-phenyl-4,5-dihydro-1H,3H-1,4-epoxybenzo[4,5]imidazo[2,1-c][1,4]oxazepin-9-ol Structure

1-phenyl-4,5-di...

Dimethyl sulfate Structure

Dimethyl sulfate

~%

4,5-dihydro-9-methoxy-1-phenyl-1,4-epoxy-1H,3H-<1,4> oxazepino <4,3-a> benzimidazole Structure

4,5-dihydro-9-m...

(5-methoxy-1(3)H-benzoimidazol-2-yl)-phenyl-methanone Structure

(5-methoxy-1(3)...

Epibromohydrin Structure

~%

1,4-Epoxy-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-8-meth oxy-1-phenyl- Structure

1,4-Epoxy-1H,3H...

4,5-dihydro-9-methoxy-1-phenyl-1,4-epoxy-1H,3H-<1,4> oxazepino <4,3-a> benzimidazole Structure

4,5-dihydro-9-m...

phenyl-(5-trifluoromethyl-1(3)H-benzoimidazol-2-yl)-methanone Structure

phenyl-(5-trifl...

Epibromohydrin Structure

~%

brn 5632391 Structure

brn 5632392 Structure

1H-benzimidazol-2-yl-(4-methylphenyl)methanone Structure

1H-benzimidazol...

~%

brn 1150484 Structure

Methanone, 1H-benzimidazol-2-yl(4-methoxyphenyl)- Structure

Methanone, 1H-b...

~%

brn 1157965 Structure

Ethylene glycol Structure

Ethylene glycol

(1-methyl-1H-benzoimidazol-2-yl)-phenyl-methanone Structure

(1-methyl-1H-be...

~82%

1-methyl-2-(2-phenyl-1,3-dioxolan-2-yl)benzimidazole Structure

1-methyl-2-(2-p...

(1H-benzo[d]imidazol-2-yl)(2-chlorophenyl)methanone Structure

(1H-benzo[d]imi...

~%

1,4-Epoxy-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-1-(2-c hlorophenyl)- Structure

1,4-Epoxy-1H,3H...

(5-methoxy-1(3)H-benzoimidazol-2-yl)-phenyl-methanone Structure

(5-methoxy-1(3)...

Epibromohydrin Structure

~%

1,4-Epoxy-1H,3H-(1,4)oxazepino(4,3-a)benzimidazole, 4,5-dihydro-8-meth oxy-1-phenyl- Structure

1,4-Epoxy-1H,3H...

4,5-dihydro-9-methoxy-1-phenyl-1,4-epoxy-1H,3H-<1,4> oxazepino <4,3-a> benzimidazole Structure

4,5-dihydro-9-m...

Methanone,1H-benzimidazol-2-ylphenyl- Structure

Methanone,1H-be...

~%

1,4-Epoxy-1H,3H-(1,4)thiazepino(4,3-a)benzimidazole, 4,5-dihydro-1-phe nyl- Structure

1,4-Epoxy-1H,3H...

(1H-Benzoimidazol-2-yl)-m-tolyl-methanol Structure

(1H-Benzoimidaz...

~%

1H-benzimidazol-2-yl-(3-methylphenyl)methanone Structure

1H-benzimidazol...

o-Phenylenediamine Structure

o-Phenylenediamine

~%

1H-benzimidazol-2-yl-(3-methylphenyl)methanone Structure

1H-benzimidazol...

3-Nitro-4-chlorobenzotrifluoride Structure

3-Nitro-4-chlor...

~%

brn 5632392 Structure

phenyl-(5-trifluoromethyl-1(3)H-benzoimidazol-2-yl)-methanone Structure

phenyl-(5-trifl...

Epibromohydrin Structure

~%

brn 5632391 Structure

brn 5632392 Structure

2-(4-fluoro-α-hydroxybenzyl)benzimidazole Structure

2-(4-fluoro-α-h...

~%

1H-benzimidazol-2-yl-(4-fluorophenyl)methanone Structure

1H-benzimidazol...

o-Phenylenediamine Structure

o-Phenylenediamine

~%

1H-benzimidazol-2-yl-(4-fluorophenyl)methanone Structure

1H-benzimidazol...