2,4-Difluoronitrobenzene

Modify Date: 2026-06-30 01:33:33

2,4-Difluoronitrobenzene structure	Common Name	2,4-Difluoronitrobenzene
	CAS Number	446-35-5	Molecular Weight	159.090
	Density	1.5±0.1 g/cm3	Boiling Point	207.0±0.0 °C at 760 mmHg
	Molecular Formula	C₆H₃F₂NO₂	Melting Point	9-10 °C(lit.)
	MSDS	Chinese USA	Flash Point	90.6±0.0 °C
	Symbol	GHS06	Signal Word	Danger

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	2,4-Difluoronitrobenzene
Synonym	More Synonyms

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.5±0.1 g/cm3
Boiling Point	207.0±0.0 °C at 760 mmHg
Melting Point	9-10 °C(lit.)
Molecular Formula	C₆H₃F₂NO₂
Molecular Weight	159.090
Flash Point	90.6±0.0 °C
Exact Mass	159.013184
PSA	45.82000
LogP	1.58
Vapour density	>1 (vs air)
Vapour Pressure	0.3±0.3 mmHg at 25°C
Index of Refraction	1.510
InChIKey	RJXOVESYJFXCGI-UHFFFAOYSA-N
SMILES	O=[N+]([O-])c1ccc(F)cc1F
Stability	Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

2,4-Difluoronitrobenzene MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ5730000

CHEMICAL NAME :: Benzene, 2,4-difluoro-1-nitro-

CAS REGISTRY NUMBER :: 446-35-5

BEILSTEIN REFERENCE NO. :: 2048034

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C6-H3-F2-N-O2

MOLECULAR WEIGHT :: 159.10

WISWESSER LINE NOTATION :: WNR BF DF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - chromodacryorrhea Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1290 mg/m3/1H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 80 nL/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 116,217,1983

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H315-H319-H335
Precautionary Statements	P261-P301 + P310-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	T:Toxic
Risk Phrases	R23/24/25;R36/37/38
Safety Phrases	S26-S45-S36/37/39-S23
RIDADR	UN 2810 6.1/PG 1
WGK Germany	3
RTECS	CZ5730000
Packaging Group	III
Hazard Class	6.1
HS Code	2904909090

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 8
CAS#:611-06-3 2,4-Dichloronit... CAS#:367-25-9 2,4-Difluoroaniline CAS#:56022-38-9 triethyl(hexade... CAS#:126-33-0 Sulfolane
CAS#:2751-90-8 TETRAPHENYLPHOS... CAS#:148854-10-8 (2,4-Difluoroph... CAS#:2369-13-3 3-Fluoro-4-nitr... CAS#:372-18-9 1,3-Difluorobenzene
DownStream 10
CAS#:55687-23-5 6-Fluoroquinoxa... CAS#:4920-84-7 2,4-Dimethoxy-1... CAS#:446-38-8 3-Fluoro-4-nitr... CAS#:448-19-1 5-Fluoro-2-nitr...
CAS#:52807-12-2 4'-Hydroxy Flur... CAS#:315228-19-4 (2-Fluoro-4-nit... CAS#:55687-33-7 2-Chloro-6-fluo... CAS#:367-25-9 2,4-Difluoroaniline
CAS#:367-27-1 2,4-Difluorophenol CAS#:345-24-4 1-BROMO-2,4-DIF...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2904909090
Summary	HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

A direct synthesis of 2-arylpropenoic acid esters having nitro groups in the aromatic ring: a short synthesis of (±)-coerulescine and (±)-horsfiline. Selvakumar N, et al.

Tetrahedron Lett. 43(50) , 9175-78, (2002)

A solid phase traceless synthesis of 2-arylaminobenzimidazoles. Krchnák V, et al.

Tetrahedron Lett. 42(9) , 1627-30, (2001)

Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography.

Angew. Chem. Int. Ed. Engl. 51(28) , 7028-30, (2012)

Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desi...

This table contains target information, in‑vitro & in‑vivo assay data for this compound.

Name: Luminescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: mu-type opioid receptor isoform MOR-1 [Homo sapiens]
External Id: OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

Name: Cell Viability Profiling of Human Lymphoblast Cell Lines
Source: NCGC
Target: N/A
External Id: HAPV101

Name: Caspase-3/7 Activation Profiling of Human Lymphoblast Cell Lines
Source: NCGC
Target: N/A
External Id: HAPC101

Name: Fluorescence-based cell-based primary high throughput screening assay to identify ago...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_AG_FLUO8_1536_1X%ACT PRUN

Name: Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
Source: 824
External Id: CYP273

Name: Fluorescence-based cell-based primary high throughput screening assay to identify pos...
Source: The Scripps Research Institute Molecular Screening Center
Target: muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id: CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

Name: Fluorescence polarization-based biochemical high throughput primary assay to identify...
Source: The Scripps Research Institute Molecular Screening Center
Target: RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens]
External Id: SIAE_INH_FP_1536_1X%INH PRUN

Name: p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
Source: 824
Target: N/A
External Id: P53600

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
Source: 824
Target: N/A
External Id: P53MS958

Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
Source: 824
External Id: P53MS482

Total 312, Current Page 1 of 32

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

2,4-difluoro-1-nitro-benzene

2.4 DFNB

2,4-difluoro-1-nitro-benzen

2,4-DIFLUORO NITROBENZEN

MFCD00007050

1,3-difluoro-4-nitrobenzene

2,4-Difluronitrobenzene

3,5-diflurobenzonitrile

2,4-Difluoronitroben

1-nitro-2,4-difluorobenzene

2,4-Difluoro-1-nitrobenzene

EINECS 207-167-0

2,4-Difluoronitribenzene

2,4-Difluoronitrobenzene

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the InChIKey of 2,4-Difluoronitrobenzene?

A: InChIKey of 2,4-Difluoronitrobenzene is RJXOVESYJFXCGI-UHFFFAOYSA-N.

Q: What is the polar surface area (PSA) of 2,4-Difluoronitrobenzene?

A: Polar surface area (PSA) of 2,4-Difluoronitrobenzene is 45.82000.

Q: What is the LogP of 2,4-Difluoronitrobenzene?

A: LogP of 2,4-Difluoronitrobenzene is 1.58.

Q: What is the SMILES notation of 2,4-Difluoronitrobenzene?

A: SMILES notation of 2,4-Difluoronitrobenzene is O=[N+]([O-])c1ccc(F)cc1F.

Q: What are the downstream products of 2,4-Difluoronitrobenzene?

A: Related downstream products(CAS) of 2,4-Difluoronitrobenzene: 55687-23-5;4920-84-7;446-38-8;448-19-1;52807-12-2;315228-19-4;55687-33-7;367-25-9;367-27-1;345-24-4.

Q: What is the melting point of 2,4-Difluoronitrobenzene?

A: Melting point of 2,4-Difluoronitrobenzene is 9-10 °C(lit.).

Q: What is the molecular weight of 2,4-Difluoronitrobenzene?

A: Molecular weight of 2,4-Difluoronitrobenzene is 159.090.

Q: What is the boiling point of 2,4-Difluoronitrobenzene?

A: Boiling point of 2,4-Difluoronitrobenzene is 207.0±0.0 °C at 760 mmHg.

Q: What is the English name of 2,4-Difluoronitrobenzene?

A: The English name of 2,4-Difluoronitrobenzene is 2,4-Difluoronitrobenzene.

Q: What is the CAS number of 2,4-Difluoronitrobenzene?

A: CAS number of 2,4-Difluoronitrobenzene is 446-35-5.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Henan Tianfu Chemical Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2,4-Difluoronitrobenzene
Price: Check
Purity: 99.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2,4-Difluoronitrobenzene
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Henan Tianfu Chemical Co., Ltd.
China
Product Name: high quality 2,4-Difluoronitrobenzene
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: 2,4-Difluoronitrobenzene
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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2,4-Difluoronitrobenzene

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Articles4

2,4-DifluoronitrobenzeneBioassay

Synonyms

2,4-Difluoronitrobenzene | FAQ

2,4-Difluoronitrobenzenefactory

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.