3-Azatetracyclo [5.2. 1.15, 8.01, 5] undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against …

…, WF DeGrado, RA Lamb, LH Pinto…

Index: Wang, Jizhou; Ma, Chunlong; Wang, Jun; Jo, Hyunil; Canturk, Belgin; Fiorin, Giacomo; Pinto, Lawrence H.; Lamb, Robert A.; Klein, Michael L.; DeGrado, William F. Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 2804 - 2812

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Citation Number: 19

Abstract

We have synthesized and characterized a series of compounds containing the 3- azatetracyclo [5.2. 1.15, 8.01, 5] undecane scaffold designed as analogues of amantadine, an inhibitor of the M2 proton channel of influenza A virus. Inhibition of the wild-type (WT) M2 channel and the amantadine-resistant A/M2-S31N and A/M2-V27A mutant ion channels were measured in Xenopus oocytes using two-electrode voltage clamp (TEV) assays. ...