e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Nucleosides & nucleotides

Structurally Altered Substrates for DNA Topoisomerase. I. Effects of Inclusion of a Single 3′-Deoxynucleotide Within the Scissile Strand†

T Arslan, AT Abraham, SM Hecht

Index: Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M. Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530

Full Text: HTML

Citation Number: 25

Abstract

Abstract A partial DNA duplex containing a high efficiency topoisomerase I cleavage site was substituted singly at each of three sites with 3′-deoxyadenosine. Depending on the site of substitution, the facility of the topoisomerase I-mediated cleavage or ligation reactions was altered. Inclusion of the modified nucleoside at the 5′-end of the acceptor oligonucleotide diminished the rate of religation following substrate cleavage by the ...

2-cyanoethyl N,N- diisopropylchlorophosphoramidite Structure

2-cyanoethyl N,...

N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE Structure

N6-BENZOYL-5'-O...

~67%

N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite Structure

N6-Bz-5'-O-DMTr...

4,4'-Dimethoxytrityl chloride Structure

4,4'-Dimethoxyt...

~%

N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite Structure

N6-Bz-5'-O-DMTr...

N6-BENZOYL-3'-DEOXYADENOSINE Structure

N6-BENZOYL-3'-D...

~%

N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite Structure

N6-Bz-5'-O-DMTr...

N-(9-trimethylsilylpurin-6-yl)benzamide Structure

N-(9-trimethyls...

~%

N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite Structure

N6-Bz-5'-O-DMTr...

N/A Structure

~%

N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite Structure

N6-Bz-5'-O-DMTr...

(R)-1-((2S,4R,5R)-4-acetoxy-5-(6-benzamido-9H-purin-9-yl)tetrahydrofuran-2-yl)ethane-1,2-diyl diacetate Structure

(R)-1-((2S,4R,5...

~%

N6-Bz-5'-O-DMTr-3'-deoxyadenosine-2'-O-CED-phosphoramidite Structure

N6-Bz-5'-O-DMTr...

N-(9-trimethylsilylpurin-6-yl)benzamide Structure

N-(9-trimethyls...

~%

N6-BENZOYL-3'-DEOXYADENOSINE Structure

N6-BENZOYL-3'-D...

(R)-1-((2S,4R,5R)-4-acetoxy-5-(6-benzamido-9H-purin-9-yl)tetrahydrofuran-2-yl)ethane-1,2-diyl diacetate Structure

(R)-1-((2S,4R,5...

~%

N6-BENZOYL-3'-DEOXYADENOSINE Structure

N6-BENZOYL-3'-D...

N/A Structure

~%

N6-BENZOYL-3'-DEOXYADENOSINE Structure

N6-BENZOYL-3'-D...

N-(9-trimethylsilylpurin-6-yl)benzamide Structure

N-(9-trimethyls...

~%

N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE Structure

N6-BENZOYL-5'-O...

(R)-1-((2S,4R,5R)-4-acetoxy-5-(6-benzamido-9H-purin-9-yl)tetrahydrofuran-2-yl)ethane-1,2-diyl diacetate Structure

(R)-1-((2S,4R,5...

~%

N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE Structure

N6-BENZOYL-5'-O...

N/A Structure

~%

N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE Structure

N6-BENZOYL-5'-O...

Nucleotides Part LXX

[Charubala, Ramamurthy; Pfleidere, Wolfgang; Suhadolnik, Robert J.; Iacono, Kathryn T.; Muto, Nicholas F.; Homan, Joseph W.; Martinand-Mari, Camille; Horvath, Susan E.; Henderson, Earl E.; Steele, Amber; Rogers, Thomas J. Helvetica Chimica Acta, 2002 , vol. 85, # 8 p. 2284 - 2299]

Nucleotides Part LXX

[Charubala, Ramamurthy; Pfleidere, Wolfgang; Suhadolnik, Robert J.; Iacono, Kathryn T.; Muto, Nicholas F.; Homan, Joseph W.; Martinand-Mari, Camille; Horvath, Susan E.; Henderson, Earl E.; Steele, Amber; Rogers, Thomas J. Helvetica Chimica Acta, 2002 , vol. 85, # 8 p. 2284 - 2299]

Nucleotides Part LXX

[Charubala, Ramamurthy; Pfleidere, Wolfgang; Suhadolnik, Robert J.; Iacono, Kathryn T.; Muto, Nicholas F.; Homan, Joseph W.; Martinand-Mari, Camille; Horvath, Susan E.; Henderson, Earl E.; Steele, Amber; Rogers, Thomas J. Helvetica Chimica Acta, 2002 , vol. 85, # 8 p. 2284 - 2299]