N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE

Modify Date: 2024-01-02 19:46:11

N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE Structure
N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE structure
Common Name N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE
CAS Number 84138-86-3 Molecular Weight 657.71
Density N/A Boiling Point N/A
Molecular Formula C38H35N5O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE


N-Benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-3′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name N-[9-[(2R,3R,5S)-5-[[(2,3-dimethoxyphenyl)-diphenylmethoxy]methyl]-3-hydroxyoxolan-2-yl]purin-6-yl]benzamide

  Biological Activity

Description N-Benzoyl-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-3′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Molecular Formula C38H35N5O6
Molecular Weight 657.71
Exact Mass 657.25900
PSA 129.85000
LogP 5.82590

 Synthetic Route

~83%

N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE Structure

N6-BENZOYL-5'-O...

CAS#:84138-86-3

Literature: Meier; Neumann; Andre; Henin; Huynh-Dinh Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7300 - 7308

~69%

N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE Structure

N6-BENZOYL-5'-O...

CAS#:84138-86-3

Literature: Charubala, Ramamurthy; Pfleidere, Wolfgang; Suhadolnik, Robert J.; Iacono, Kathryn T.; Muto, Nicholas F.; Homan, Joseph W.; Martinand-Mari, Camille; Horvath, Susan E.; Henderson, Earl E.; Steele, Amber; Rogers, Thomas J. Helvetica Chimica Acta, 2002 , vol. 85, # 8 p. 2284 - 2299

~%

N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE Structure

N6-BENZOYL-5'-O...

CAS#:84138-86-3

Literature: GILEAD SCIENCES, INC., Patent: WO2008/5542 A2, 2008 ; Location in patent: Page/Page column 256-257 ;

~%

N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE Structure

N6-BENZOYL-5'-O...

CAS#:84138-86-3

Literature: Meier; Neumann; Andre; Henin; Huynh-Dinh Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7300 - 7308

~%

N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE Structure

N6-BENZOYL-5'-O...

CAS#:84138-86-3

Literature: Meier; Neumann; Andre; Henin; Huynh-Dinh Journal of Organic Chemistry, 1992 , vol. 57, # 26 p. 7300 - 7308

~%

N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE Structure

N6-BENZOYL-5'-O...

CAS#:84138-86-3

Literature: Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M. Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530

~%

N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE Structure

N6-BENZOYL-5'-O...

CAS#:84138-86-3

Literature: Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M. Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530

~%

N6-BENZOYL-5'-O-(DIMETHOXYTRITYL)-3'-DEOXYADENOSINE Structure

N6-BENZOYL-5'-O...

CAS#:84138-86-3

Literature: Arslan, Tuncer; Abraham, Anil T.; Hecht, Sidney M. Nucleosides and Nucleotides, 1998 , vol. 17, # 1-3 p. 515 - 530