Synthesis and biological activity of desmethoxy analogues of coruscanone A

…, M Špulák, J Kuneš, I Votruba, V Buchta, M Pour

Index: Tichotova, Lucie; Matousova, Eliska; Spulak, Marcel; Kunes, Jiri; Votruba, Ivan; Buchta, Vladimir; Pour, Milan Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 20 p. 6062 - 6066

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Citation Number: 10

Abstract

A series of simple desmethoxy analogues of coruscanone A was prepared via a novel version of Ti (iPrO) 4-mediated Knoevenagel condensation of cyclopentenedione with substituted benzaldehydes and cinnamic aldehydes, and the compounds were evaluated for antifungal activity and cytotoxicity. The most potent 2-benzylidenecyclopent-4-ene-1, 3- dione possessed antifungal effect comparable to coruscanone A and a somewhat broader ...