e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron
The 'SuperQuat'(R)-4-phenyl-5, 5-dimethyl oxazolidin-2-one as an effective chiral auxiliary for conjugate additions: Asymmetric synthesis of (−)-Aplysillamide B
SG Davies, HJ Sanganee, P Szolcsanyi
Index: Davies, Stephen G.; Sanganee, Hitesh J.; Szolcsanyi, Peter Tetrahedron, 1999 , vol. 55, # 11 p. 3337 - 3354
(R)-4-Phenyl-5, 5-dimethyl-oxazolidin-2-one, readily available from d-phenylglycine, is shown to be an effective chiral auxiliary for stereoselective conjugate additions to attached α, β-unsaturated N-acyl moieties. Its utility is demonstrated by the asymmetric synthesis of the antifungal, antibacterial (−)-Aplysillamide B.
[Bull, Steven D.; Davies, Stephen G.; Nicholson, Rebecca L.; Sanganee, Hitesh J.; Smith, Andrew D. Organic and Biomolecular Chemistry, 2003 , vol. 1, # 16 p. 2886 - 2899]
