Synthesis and evaluation of verticipyrone analogues as mitochondrial complex I inhibitors

SJ Leiris, OM Khdour, ZJ Segerman, KS Tsosie…

Index: Leiris, Simon J.; Khdour, Omar M.; Segerman, Zachary J.; Tsosie, Krystal S.; Chapuis, Jean-Charles; Hecht, Sidney M. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 10 p. 3481 - 3493

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Citation Number: 11

Abstract

Verticipyrone has recently been isolated from the culture broth of Verticillium sp. and shown to inhibit NADH fumarate reductase, as well as NADH oxidoreductase (complex I) of the mitochondrial electron transport chain. In order to assess the structural elements in verticipyrone essential for complex I inhibitor, 15 structural analogues were prepared and analyzed for their effects on mitochondrial NADH oxidoreductase and NADH oxidase ...