Tetrahedron letters

A convenient method for phosphorylation involving a facile oxidation of H-phosphonate monoesters via bis (trimethylsilyl) phosphites

T Wada, A Mochizuki, Y Sato, M Sekine

Index: Wada, Takeshi; Mochizuki, Akira; Sato, Yuichi; Sekine, Mitsuo Tetrahedron Letters, 1998 , vol. 39, # 39 p. 7123 - 7126

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Citation Number: 49

Abstract

A new convenient route to phosphate monoesters from alcohols has been developed. H- Phosphonate monoesters, which are readily accessible by phosphonylation of the parent alcohols, were oxidized with t-BuOOH or N-sulfonyloxaziridines under anhydrous conditions via the corresponding bis (trimethylsilyl) phosphites. N, O-Bis (trimethylsilyl) benzamide (BSB) and (camphorsulfonyl) oxaziridine (CSO) were found to be highly effective for ...