Design, synthesis and neuroprotective evaluation of novel tacrine–benzothiazole hybrids as multi-targeted compounds against Alzheimer's disease

…, C Quintanova, SM Marques, AR Esteves…

Index: Keri, Rangappa S.; Quintanova, Catarina; Marques, Sergio M.; Esteves, A. Raquel; Cardoso, Sandra M.; Santos, M. Amelia Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 15 p. 4559 - 4569

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Citation Number: 27

Abstract

Alzheimer's disease (AD) is a multifactorial disorder with several target proteins contributing to its etiology. In search for multifunctional anti-AD drug candidates, taking into account that the acetylcholinesterase (AChE) and beta-amyloid (Aβ) aggregation are particularly important targets for inhibition, the tacrine and benzothiazole (BTA) moieties were conjugated with suitable linkers in a novel series of hybrids. The designed compounds (7a ...