6-Aminocaproic acid

Modify Date: 2026-06-30 16:48:22

6-Aminocaproic acid structure	Common Name	6-Aminocaproic acid
	CAS Number	60-32-2	Molecular Weight	131.173
	Density	1.0±0.1 g/cm3	Boiling Point	255.6±23.0 °C at 760 mmHg
	Molecular Formula	C₆H₁₃NO₂	Melting Point	207-209 °C (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	108.4±22.6 °C

Use of 6-Aminocaproic acid

6-Aminocaproic acid is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.Target: Others6-aminohexanoic acid is a derivative and analogue of the amino acid lysine, which makes it an effective inhibitor for enzymes that bind that particular residue. Such enzymes include proteolytic enzymes like plasmin, the enzyme responsible for fibrinolysis. Aminocaproic acid is also an intermediate in the polymerization of Nylon-6, where it is formed by ring-opening hydrolysis of caprolactam.Aminocaproic acid is used to treat excessive postoperative bleeding, especially after procedures in which a great amount of bleeding is expected, such as cardiac surgery. Aminocaproic acid can also be used to treat the overdose and/or toxic effects of the thrombolytic pharmacologic agents tissue plasminogen activator and streptokinase [1, 2].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	6-aminohexanoate
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	6-Aminocaproic acid is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.Target: Others6-aminohexanoic acid is a derivative and analogue of the amino acid lysine, which makes it an effective inhibitor for enzymes that bind that particular residue. Such enzymes include proteolytic enzymes like plasmin, the enzyme responsible for fibrinolysis. Aminocaproic acid is also an intermediate in the polymerization of Nylon-6, where it is formed by ring-opening hydrolysis of caprolactam.Aminocaproic acid is used to treat excessive postoperative bleeding, especially after procedures in which a great amount of bleeding is expected, such as cardiac surgery. Aminocaproic acid can also be used to treat the overdose and/or toxic effects of the thrombolytic pharmacologic agents tissue plasminogen activator and streptokinase [1, 2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Natural Products >> Others
References	[1]. Gardner, F.H. and R.E. Helmer, 3rd, Aminocaproic acid. Use in control of hemorrhage in patients with amegakaryocytic thrombocytopenia. JAMA, 1980. 243(1): p. 35-7. [2]. Schwartz, B.S., et al., Epsilon-aminocaproic acid in the treatment of patients with acute promyelocytic leukemia and acquired alpha-2-plasmin inhibitor deficiency. Ann Intern Med, 1986. 105(6): p. 873-7.

Description

Related Catalog

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

Natural Products >> Others

References

[1]. Gardner, F.H. and R.E. Helmer, 3rd, Aminocaproic acid. Use in control of hemorrhage in patients with amegakaryocytic thrombocytopenia. JAMA, 1980. 243(1): p. 35-7.

[2]. Schwartz, B.S., et al., Epsilon-aminocaproic acid in the treatment of patients with acute promyelocytic leukemia and acquired alpha-2-plasmin inhibitor deficiency. Ann Intern Med, 1986. 105(6): p. 873-7.

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.0±0.1 g/cm3
Boiling Point	255.6±23.0 °C at 760 mmHg
Melting Point	207-209 °C (dec.)(lit.)
Molecular Formula	C₆H₁₃NO₂
Molecular Weight	131.173
Flash Point	108.4±22.6 °C
Exact Mass	131.094635
PSA	63.32000
LogP	-0.11
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.467
InChIKey	SLXKOJJOQWFEFD-UHFFFAOYSA-N
SMILES	NCCCCCC(=O)O
Water Solubility	SOLUBLE

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

6-Aminocaproic acid MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MO6300000

CHEMICAL NAME :: Hexanoic acid, 6-amino-

CAS REGISTRY NUMBER :: 60-32-2

BEILSTEIN REFERENCE NO. :: 0906872

LAST UPDATED :: 199806

DATA ITEMS CITED :: 21

MOLECULAR FORMULA :: C6-H13-N-O2

MOLECULAR WEIGHT :: 131.20

WISWESSER LINE NOTATION :: Z5VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,738,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 1778 mg/kg/8D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - hematuria Nutritional and Gross Metabolic - body temperature increase

REFERENCE :: AJKDDP American Journal of Kidney Diseases. (Grune & Stratton, Inc., Journal Subscription Dept., POB 6280, Duluth, MN 55806) V.1- 1981- Volume(issue)/page/year: 8,441,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Multiple routes

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 14400 mg/kg/59D-I

TOXIC EFFECTS :: Behavioral - muscle weakness Kidney, Ureter, Bladder - hematuria

REFERENCE :: BJURAN British Journal of Urology. (Longman Group Ltd., POB 11318, Birmingham, AL 35202) V.1- 1929- Volume(issue)/page/year: 60,81,1987

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 3,62,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 3,62,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 3,62,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 14300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,79,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,62,1995

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4900 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AAREAV Anesthesie, Analgesie, Reanimation. (Paris, France) V.14-38, 1957-81. Volume(issue)/page/year: 22,481,1965

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,79,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2150 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 3,62,1961

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: >7 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,79,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,79,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 19800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AAREAV Anesthesie, Analgesie, Reanimation. (Paris, France) V.14-38, 1957-81. Volume(issue)/page/year: 22,481,1965 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 32500 mg/kg/13W-I

TOXIC EFFECTS :: Cardiac - changes in heart weight Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 22,340,1965

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 337 gm/kg/30D-C

TOXIC EFFECTS :: Behavioral - excitement Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959- Volume(issue)/page/year: 3,62,1961 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 153 gm/kg

SEX/DURATION :: female 40 day(s) pre-mating female 1-21 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 22,340,1965

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 190 gm/kg

SEX/DURATION :: male 38 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

REFERENCE :: APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 3,115,1966

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intrauterine

DOSE :: 15 mg/kg

SEX/DURATION :: female 6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969- Volume(issue)/page/year: 23,553,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5412 No. of Facilities: 609 (estimated) No. of Industries: 2 No. of Occupations: 8 No. of Employees: 11144 (estimated) No. of Female Employees: 8251 (estimated)

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	MO6300000
HS Code	29224995

This table lists upstream starting materials and downstream derivative products related to this chemical.

Precursor 9
CAS#:1947-00-8 N-Benzyloxycarb... CAS#:100-64-1 Cyclohexanone oxime CAS#:1201194-72-0 6-(dibenzylamin... CAS#:5515-01-5 benzyl 6-aminoh...
CAS#:105-60-2 Caprolactam CAS#:64-17-5 Ethanol CAS#:13111-36-9 6-(4-nitrobenzy... CAS#:10269-96-2 6-Nitrohexanoic acid
CAS#:57-08-9 6-Acetamidohexa...
DownStream 10
CAS#:104807-40-1 METHOCTRAMINE H... CAS#:55750-53-3 6-Maleimidocapr... CAS#:55750-63-5 N-Succinimidyl ... CAS#:4224-70-8 6-Bromohexanoic acid
CAS#:371-34-6 Ethyl 6-Aminohe... CAS#:367927-39-7 SMPH Crosslinker CAS#:4048-33-3 6-Aminohexan-1-ol CAS#:462-94-2 Cadaverine
CAS#:51513-80-5 6-[[(1,1-Dimeth... CAS#:5100-36-7 ETHYL 6-ISOCYAN...

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

ε-aminocaproic acid

N-Cbz-ε-aminocaproic Acid

6-Aminocaproic acid

6-amino hexanoic acid

HEXANOIC ACID,6-AMINO

w-Aminocaproic acid

Aminohexanoic acid

Acidum Aminocaproicum

Aminocaproic acid

6-(((Benzyloxy)carbonyl)amino)hexanoic acid

6-[N-(Benzyloxycarbonyl)amino]hexanoic acid

6-amino-n-hexanoic acid

H-6-Aca-OH

ε-Amino-n-caproic acid

6-amino-hexanoic acid

N-Cbz-6-aminocaproic acid

N-benzyloxycarbonyl-6-aminohexanoic acid

N-Carbobenzoxy-ε-aminocaproic Acid

acido aminocaproico

H-ε-Acp-OH

ε-aminohexanoic acid

H-EAhx-OH

6-{[(Benzyloxy)carbonyl]amino}hexanoic acid

N-Carbobenzoxy-6-aminohexanoic Acid

6-amino-n-caproic acid

4-aminobutyltrimethoxysilane

N-(Benzyloxycarbonyl)-6-aminohexanoic acid

MFCD00008238

H-6-Ahx-OH

6-[(phenylmethoxy)carbonylamino]hexanoic acid

w-Aminohexanoic acid

N-Cbz-6-aminohexanoic Acid

EINECS 200-469-3

Z-6-Aminohexanoic acid

Cbz-ε- Aminocaproic acid

4-04-00-02695 (Beilstein Handbook Reference)

AMICAR

N-Benzyloxycarbonyl-6-aminocaproic Acid

6-Aminohexanoic acid

6-N-Cbz-aminohexanoic acid

aminobutyltrimethoxysilane

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What are the downstream products of 6-aminohexanoate?

A: Related downstream products(CAS) of 6-aminohexanoate: 104807-40-1;55750-53-3;55750-63-5;4224-70-8;371-34-6;367927-39-7;4048-33-3;462-94-2;51513-80-5;5100-36-7.

Q: What is the CAS number of 6-aminohexanoate?

A: CAS number of 6-aminohexanoate is 60-32-2.

Q: What is the polar surface area (PSA) of 6-aminohexanoate?

A: Polar surface area (PSA) of 6-aminohexanoate is 63.32000.

Q: What is the LogP of 6-aminohexanoate?

A: LogP of 6-aminohexanoate is -0.11.

Q: What is the InChIKey of 6-aminohexanoate?

A: InChIKey of 6-aminohexanoate is SLXKOJJOQWFEFD-UHFFFAOYSA-N.

Q: What is the safety information for 6-aminohexanoate?

A: Safety information for 6-aminohexanoate: S26-S36.

Q: What is the SMILES notation of 6-aminohexanoate?

A: SMILES notation of 6-aminohexanoate is NCCCCCC(=O)O.

Q: What is the melting point of 6-aminohexanoate?

A: Melting point of 6-aminohexanoate is 207-209 °C (dec.)(lit.).

Q: What is the English name of 6-aminohexanoate?

A: The English name of 6-aminohexanoate is 6-aminohexanoate.

Q: What are the upstream materials of 6-aminohexanoate?

A: Related upstream materials(CAS) of 6-aminohexanoate: 1947-00-8;100-64-1;1201194-72-0;5515-01-5;105-60-2;64-17-5;13111-36-9;10269-96-2;57-08-9.

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Henan Tianfu Chemical Co., Ltd.

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Henan Tianfu Chemical Co., Ltd.
China
Product Name: 6-Aminocaproic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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6-Aminocaproic acid

Use of 6-Aminocaproic acid

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