Heptafluoro-p-tolyl and tetrafluoro-4-pyridyl as novel and selective protecting groups for phenolic and alcoholic functions: synthesis and cleavage of perfluoroaryl …

M Jarman, R McCague

Index: Jarman, Michael; McCague, Raymond Journal of the Chemical Society, Chemical Communications, 1984 , # 2 p. 125 - 127

Full Text: HTML

Citation Number: 9

Abstract

Perfluoroarenes react readily with a variety of nucleophiles and thus have potential as reagents for protecting reactive functional groups, but their use for this purpose has been little explored. Hexafluorobenzene has been used to protect carboxy functions as pentafluorophenyl esters during the synthesis of peptides. 1 Pentafluorophenyl ethers of carbo- hydrates have been described, but attempts to cleave them were unsuccessful.2 We have investigated the ...