e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Design, synthesis and antitumor activity of novel cis-furoquinoline derivatives

…, S Pei, Y Zhu, J Wu, Y Chen, W Zhang…

Index: Li, Jie; Pei, Shuchen; Zhu, Yingxi; Wu, Jianbo; Chen, Yin; Zhang, Weiyu; Wu, Yong Letters in Drug Design and Discovery, 2012 , vol. 9, # 4 p. 379 - 388

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Citation Number: 2

Abstract

A series of novel cis-furoquinoline derivatives was synthesized and tested for their antitumor activities in vitro against HepG2 cells, Lu-04 cells and Leu02 cells to evaluate structure- activity relationships. Assay-based antiproliferative activity study revealed that several compounds had significant effects on cytotoxicity, among which compounds 2f, 2l, 2q were found to be the most active compounds. Above all, compounds 2f, 2l, 2q would be ...

Benzene,1-methoxy-4-(4-nitrophenoxy)- Structure

Benzene,1-metho...

~%

4-(4-butoxyphenoxy)aniline Structure

4-(4-butoxyphen...

4-(4-nitrophenoxy)phenol Structure

4-(4-nitropheno...

~%

4-(4-butoxyphenoxy)aniline Structure

4-(4-butoxyphen...

1-(4-butoxyphenoxy)-4-nitrobenzene Structure

1-(4-butoxyphen...

~%

4-(4-butoxyphenoxy)aniline Structure

4-(4-butoxyphen...

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~%

4-(4-butoxyphenoxy)aniline Structure

4-(4-butoxyphen...

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~%

4-(4-nitrophenoxy)phenol Structure

4-(4-nitropheno...

4-Aminophenol Structure

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~59%

4-(4-nitroanilino)phenol Structure

4-(4-nitroanili...

Mequinol Structure

~%

4-(4-butoxyphenoxy)aniline Structure

4-(4-butoxyphen...

4-[(4-nitrophenyl)sulfanyl]phenol Structure

4-[(4-nitrophen...

~92%

1-(4-butoxyphenyl)sulfanyl-4-nitrobenzene Structure

1-(4-butoxyphen...

4-Methoxythiophenol Structure

4-Methoxythiophenol

~%

1-(4-butoxyphenyl)sulfanyl-4-nitrobenzene Structure

1-(4-butoxyphen...

N/A Structure

~%

1-(4-butoxyphenyl)sulfanyl-4-nitrobenzene Structure

1-(4-butoxyphen...

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~%

1-(4-butoxyphenyl)sulfanyl-4-nitrobenzene Structure

1-(4-butoxyphen...

Benzene,1-methoxy-4-(4-nitrophenoxy)- Structure

Benzene,1-metho...

~%

4-(4-ETHOXYPHENOXY)ANILINE HYDROCHLORIDE Structure

4-(4-ETHOXYPHEN...

4-(4-nitrophenoxy)phenol Structure

4-(4-nitropheno...

~%

4-(4-ETHOXYPHENOXY)ANILINE HYDROCHLORIDE Structure

4-(4-ETHOXYPHEN...

1-(4-ethoxyphenoxy)-4-nitrobenzene Structure

1-(4-ethoxyphen...

~%

4-(4-ETHOXYPHENOXY)ANILINE HYDROCHLORIDE Structure

4-(4-ETHOXYPHEN...

Mequinol Structure

~%

4-(4-ETHOXYPHENOXY)ANILINE HYDROCHLORIDE Structure

4-(4-ETHOXYPHEN...

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~%

4-(4-ETHOXYPHENOXY)ANILINE HYDROCHLORIDE Structure

4-(4-ETHOXYPHEN...

4-(4-nitroanilino)phenol Structure

4-(4-nitroanili...

~94%

N-(4-ethoxyphenyl)-4-nitroaniline Structure

N-(4-ethoxyphen...

4-Aminophenol Structure

~%

N-(4-ethoxyphenyl)-4-nitroaniline Structure

N-(4-ethoxyphen...

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~%

N-(4-ethoxyphenyl)-4-nitroaniline Structure

N-(4-ethoxyphen...

4-Methoxythiophenol Structure

4-Methoxythiophenol

~%

4-(4-butoxyphenyl)sulfanylaniline Structure

4-(4-butoxyphen...

N/A Structure

~%

4-(4-butoxyphenyl)sulfanylaniline Structure

4-(4-butoxyphen...

1-(4-butoxyphenyl)sulfanyl-4-nitrobenzene Structure

1-(4-butoxyphen...

~%

4-(4-butoxyphenyl)sulfanylaniline Structure

4-(4-butoxyphen...

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~%

4-(4-butoxyphenyl)sulfanylaniline Structure

4-(4-butoxyphen...

N-(4-nitrophenyl)naphthalen-2-amine Structure

N-(4-nitropheny...

~%

1,4-Benzenediamine,N1-2-naphthalenyl- Structure

1,4-Benzenediam...

Naphthalen-2-amine Structure

Naphthalen-2-amine

~%

1,4-Benzenediamine,N1-2-naphthalenyl- Structure

1,4-Benzenediam...

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~%

1,4-Benzenediamine,N1-2-naphthalenyl- Structure

1,4-Benzenediam...

4-[(4-nitrophenyl)sulfanyl]phenol Structure

4-[(4-nitrophen...

~%

4-(4-butoxyphenyl)sulfanylaniline Structure

4-(4-butoxyphen...

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

p-Phenylenediamine Structure

p-Phenylenediamine

~56%

1,4-Benzenediamine,N1-(4-nitrophenyl)- Structure

1,4-Benzenediam...

4-(4-nitroanilino)phenol Structure

4-(4-nitroanili...

~93%

N-(4-methoxyphenyl)-4-nitroaniline Structure

N-(4-methoxyphe...

4-Aminophenol Structure

~%

N-(4-methoxyphenyl)-4-nitroaniline Structure

N-(4-methoxyphe...

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~%

N-(4-methoxyphenyl)-4-nitroaniline Structure

N-(4-methoxyphe...

4-Aminophenol Structure

~%

4-(4-aminoanilino)phenol Structure

4-(4-aminoanili...

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~%

4-(4-aminoanilino)phenol Structure

4-(4-aminoanili...

4-(4-nitrophenoxy)phenol Structure

4-(4-nitropheno...

~92%

1-(4-ethoxyphenoxy)-4-nitrobenzene Structure

1-(4-ethoxyphen...

Benzene,1-methoxy-4-(4-nitrophenoxy)- Structure

Benzene,1-metho...

~%

1-(4-ethoxyphenoxy)-4-nitrobenzene Structure

1-(4-ethoxyphen...

Mequinol Structure

~%

1-(4-ethoxyphenoxy)-4-nitrobenzene Structure

1-(4-ethoxyphen...

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~%

1-(4-ethoxyphenoxy)-4-nitrobenzene Structure

1-(4-ethoxyphen...

4-(4-nitrophenoxy)phenol Structure

4-(4-nitropheno...

~90%

1-(4-butoxyphenoxy)-4-nitrobenzene Structure

1-(4-butoxyphen...

Benzene,1-methoxy-4-(4-nitrophenoxy)- Structure

Benzene,1-metho...

~%

1-(4-butoxyphenoxy)-4-nitrobenzene Structure

1-(4-butoxyphen...

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~%

1-(4-butoxyphenoxy)-4-nitrobenzene Structure

1-(4-butoxyphen...

p-Toluidine Structure

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~61%

Benzenamine,4-methyl-N-(4-nitrophenyl)- Structure

Benzenamine,4-m...

Mequinol Structure

~%

1-(4-butoxyphenoxy)-4-nitrobenzene Structure

1-(4-butoxyphen...

4-Methoxythiophenol Structure

4-Methoxythiophenol

~%

4-(4-ethoxyphenyl)sulfanylaniline Structure

4-(4-ethoxyphen...

N/A Structure

~%

4-(4-ethoxyphenyl)sulfanylaniline Structure

4-(4-ethoxyphen...

4-[(4-nitrophenyl)sulfanyl]phenol Structure

4-[(4-nitrophen...

~%

4-(4-ethoxyphenyl)sulfanylaniline Structure

4-(4-ethoxyphen...

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~%

4-(4-ethoxyphenyl)sulfanylaniline Structure

4-(4-ethoxyphen...

2-Anisidine Structure

~%

4-N-(2-methoxyphenyl)benzene-1,4-diamine Structure

4-N-(2-methoxyp...

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~%

4-N-(2-methoxyphenyl)benzene-1,4-diamine Structure

4-N-(2-methoxyp...

Benzenamine,4-methyl-N-(4-nitrophenyl)- Structure

Benzenamine,4-m...

~%

N1-(P-TOLYL)BENZENE-1,4-DIAMINE Structure

N1-(P-TOLYL)BEN...

p-Toluidine Structure

~%

N1-(P-TOLYL)BENZENE-1,4-DIAMINE Structure

N1-(P-TOLYL)BEN...

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~%

N1-(P-TOLYL)BENZENE-1,4-DIAMINE Structure

N1-(P-TOLYL)BEN...

4-(4-nitroanilino)phenol Structure

4-(4-nitroanili...

~%

4-N-(4-ethoxyphenyl)benzene-1,4-diamine Structure

4-N-(4-ethoxyph...

4-Aminophenol Structure

~%

4-N-(4-ethoxyphenyl)benzene-1,4-diamine Structure

4-N-(4-ethoxyph...

1-Fluoro-4-nitrobenzene Structure

1-Fluoro-4-nitr...

~%

4-N-(4-ethoxyphenyl)benzene-1,4-diamine Structure

4-N-(4-ethoxyph...