2-Aminoethoxydiphenyl borate as a prototype drug for a group of structurally related calcium channel blockers in human platelets

Y Dobrydneva, CJ Abelt, B Dovel, CM Thadigiri…

Index: Dobrydneva, Yuliya; Abelt, Christopher J.; Dovel, Beth; Thadigiri, Celina M.; Williams, Roy L.; Blackmore, Peter F. Molecular Pharmacology, 2006 , vol. 69, # 1 p. 247 - 256

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Citation Number: 25

Abstract

Abstract We have synthesized a series of 2-aminoethoxydiphenyl borate (2-APB, 2, 2- diphenyl-1, 3, 2-oxazaborolidine) analogs and tested their ability to inhibit thrombin-induced Ca 2+ influx in human platelets. The analogs were either synthesized by adding various substituents to the oxazaborolidine ring (methyl, dimethyl, tert-butyl, phenyl, methyl phenyl, and pyridyl) or increasing the size of the oxazaborolidine ring to seven-and nine- ...