e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

A fast and simple method for the acylation of alcohols with acid chlorides promoted by metallic samarium

XS Jia, HL Wang, Q Huang, LL Kong…

Index: Jia, Xue-Shun; Wang, Hai-Long; Huang, Qing; Kong, Ling-Long; Zhang, Wei-He Journal of Chemical Research, 2006 , # 2 p. 135 - 138

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Citation Number: 2

Abstract

Carboxylic acid esters are well known for their applications in organic synthesis and their activity in the field of medicine. The commonly employed synthetic method is the acylation of alcohols with acid chlorides. In general, the acylations occur by the reaction in the presence of a base such as pyridine, TMEDA or triethylamine.1 Further, various catalysts have been developed for the acylation of alcohols with acid chlorides such as zinc chloride2 or alumina.3 However, ...

pentanol Structure

Phenylacetyl chloride Structure

Phenylacetyl ch...

~96%

Amyl phenylacetate Structure

Amyl phenylacetate

p-Anisoyl chloride Structure

p-Anisoyl chloride

Isopropanol Structure

~94%

Benzoic acid,4-methoxy-, 1-methylethyl ester Structure

Benzoic acid,4-...

Ciprofloxacin Hydrochloride Structure

Ciprofloxacin H...

Isopropanol Structure

~86%

Isopropyl (2E)-3-phenylacrylate Structure

Isopropyl (2E)-...

pentanol Structure

Ciprofloxacin Hydrochloride Structure

Ciprofloxacin H...

~78%

3-Methylbutyl (2E)-3-phenylacrylate Structure

3-Methylbutyl (...

4-Chlorobenzoyl chloride Structure

4-Chlorobenzoyl...

Benzyl alcohol Structure

~3%

1,2-bis(4-chlorophenyl)ethanone Structure

1,2-bis(4-chlor...

Benzoic acid, 4-chloro-, phenylmethyl ester Structure

Benzoic acid, 4...

4-Chlorobenzoyl chloride Structure

4-Chlorobenzoyl...

Isopropanol Structure

~10%

1,2-bis(4-chlorophenyl)ethanone Structure

1,2-bis(4-chlor...

4-Chlorobenzoic acid isopropyl ester Structure

4-Chlorobenzoic...

Cinnamyl alcohol Structure

Cinnamyl alcohol

Phenylacetyl chloride Structure

Phenylacetyl ch...

~72%

cinnamyl phenyl acetate Structure

cinnamyl phenyl...

4-Chlorobenzoyl chloride Structure

4-Chlorobenzoyl...

Benzyl alcohol Structure

~87%

1,2-bis(4-chlorophenyl)ethanone Structure

1,2-bis(4-chlor...

Benzoic acid, 4-chloro-, phenylmethyl ester Structure

Benzoic acid, 4...

pentanol Structure

p-Anisoyl chloride Structure

p-Anisoyl chloride

~95%

Benzoic acid,4-methoxy-, pentyl ester Structure

Benzoic acid,4-...

Cinnamyl alcohol Structure

Cinnamyl alcohol

Benzoyl chloride Structure

Benzoyl chloride

~79%

Cinnamyl benzoate Structure

Cinnamyl benzoate

p-Anisoyl chloride Structure

p-Anisoyl chloride

Benzyl alcohol Structure

~91%

Benzoic acid,4-methoxy-, phenylmethyl ester Structure

Benzoic acid,4-...

4-Nitrobenzoyl chloride Structure

4-Nitrobenzoyl ...

Isopropanol Structure

~18%

Benzoicacid, 4-nitro-, 1-methylethyl ester Structure

Benzoicacid, 4-...

Isopropanol Structure

Phenylacetyl chloride Structure

Phenylacetyl ch...

~90%

isopropyl phenyl acetate Structure

isopropyl pheny...

p-toluoyl chloride Structure

p-toluoyl chloride

Benzyl alcohol Structure

~87%

1,2-bis(4-methylphenyl)ethanone Structure

1,2-bis(4-methy...

benzyl 4-methylbenzoate Structure

benzyl 4-methyl...

p-toluoyl chloride Structure

p-toluoyl chloride

Isopropanol Structure

~1%

Benzoic acid,4-methyl-, 1-methylethyl ester Structure

Benzoic acid,4-...

1,2-bis(4-methylphenyl)ethanone Structure

1,2-bis(4-methy...

p-toluoyl chloride Structure

p-toluoyl chloride

Benzyl alcohol Structure

~6%

1,2-bis(4-methylphenyl)ethanone Structure

1,2-bis(4-methy...

benzyl 4-methylbenzoate Structure

benzyl 4-methyl...