Novel sixteen chalcones and thirteen 1, 3, 5-triphenyl-2-pyrazolines were synthesized and characterized using FT-IR, HR-Mass, NMR (1H-NMR, 13C-NMR, 135 DEPT, 1H–1H CoSY and 1H and 13C CoSY) and XRD. These compounds were evaluated for their antibacterial activity against six micro-organisms, namely Bacillus subtilis NCIM 2718, Staphylococcus aureus NCIM 5021, Salmonella typhi NCIM 2501, Enterobacter aerogenes NCIM 5139, ...