Heteroaromatic Nucleophilic Substitution Reactions by Phase??Transfer Catalysis–Synthesis of New Alkoxypridazin??3 (2H)??ones

…, V Gómez??Parra, F Sánchez, TS Torres

Index: Gomez-Parra, Vicente; Sanchez, Felix; Torres, Tomas Synthesis, 1985 , # 3 p. 282 - 285

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Citation Number: 2

Abstract

Abstract The synthesis of several 4-and 5-alkoxy-substituted pyridazin-3 (2H)-ones with hypotensive and β-blocking activities by phase-transfer catalysis (PTC) starting from halopyridazin-3 (2H)-ones is described. The nucleophilic displacement reaction proceeds easily at the 5-position and remarkably slower at the 4-position. In the case of 4, 5- dihalopyridazin-3 (2H)-ones the PTC methods provide a high regioselectivity towards ...