Tetrahedron Letters

DBU-promoted alkylation of alkyl phosphinates and H-phosphonates

L Gavara, C Petit, JL Montchamp

Index: Gavara, Laurent; Petit, Christelle; Montchamp, Jean-Luc Tetrahedron Letters, 2012 , vol. 53, # 37 p. 5000 - 5003

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Citation Number: 14

Abstract

The alkylation of alkyl phosphinates and some H-phosphonate diesters is promoted by the base DBU. Only more reactive alkyl halides react in preparatively useful yields. However, the method provides easy access to important H-phosphinate building blocks, without the need for a protecting group strategy or metal catalysts. The reaction is conveniently conducted at, or below, room temperature. The preparation of methyl-H-phosphinate ...