Tetrahedron Letters

Toward waste-free peptide synthesis using ionic reagents and ionic liquids as solvents

N Galy, MR Mazières, JC Plaquevent

Index: Galy, Nicolas; Mazieres, Marie-Rose; Plaquevent, Jean-Christophe Tetrahedron Letters, 2013 , vol. 54, # 21 p. 2703 - 2705

Full Text: HTML

Citation Number: 6

Abstract

Some years ago, we disclosed our first approach about peptide synthesis in ionic liquids, in which we described that these unconventional solvents were quite convenient for this process. Indeed, we observed high conversions even for the coupling of hindered amino acids, as well as purification simplified thanks to the rather pure crude material obtained. 7 Most of these results, along with other aspects of ionic liquids related to peptide chemistry, have ...