Organic letters

Palladium-catalyzed hydroxycarbonylation of aryl and vinyl halides or triflates by acetic anhydride and formate anions

S Cacchi, G Fabrizi, A Goggiamani

Index: Cacchi, Sandro; Fabrizi, Giancarlo; Goggiamani, Antonella Organic Letters, 2003 , vol. 5, # 23 p. 4269 - 4272

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Citation Number: 72

Abstract

The palladium-catalyzed reaction of aryl and vinyl halides or triflates in the presence of acetic anhydride and lithium formate as a condensed source of carbon monoxide provides an efficient simple route to the synthesis of the corresponding carboxylic acids. The reaction proceeds very smoothly under mild conditions and tolerates a wide range of functional groups, including ether, ketone, ester, and nitro groups. The presence of ortho ...