e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Aminoalkylation of 10??Hydroxycamptothecin Using Methylene Chloride Under Solid–Liquid Phase Transfer Catalysis: A New Approach for the Preparation of …
Abstract The use of dichloromethane as a reagent, for the preparation of Topotecan {(4 S)?? 10??(dimethylamino) methyl??4??ethyl??4, 9??dihydroxy??1??H??pyrano [3′, 4′: 6, 7] indolizino?? [1, 2??b] quinoline??3, 14 (4H, 12H) dione} from 10??hydroxy??camptothecin under solid–liquid phase transfer catalysis, which behaves both as a solvent and a reagent serving as for C??1 unit source for amino??alkylation of 10??hydroxy??(4 S)??camptothecin.# US Patent no. ...
