Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers

M Gao, KD Miller, GW Sledge, QH Zheng

Index: Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3865 - 3869

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Citation Number: 13

Abstract

Four carbon-11-labeled camptothecin derivatives, 9-[11C] methoxy-20 (S)-camptothecin ([11C] 5), 10-[11C] methoxy-20 (S)-camptothecin ([11C] 7), 9-nitro-10-[11C] methoxy-20 (S)- camptothecin ([11C] 9), and 9-[([11C] trimethylamino) methyl]-10-hydroxy-20 (S)- camptothecin ([11C] 11), have been synthesized as potential positron emission tomography tracers for imaging of topoisomerase I in cancers.