FEBS Letters 2014-05-02

Unsaturated lipids protect the integral membrane peptide gramicidin A from singlet oxygen

Tatyana I. Rokitskaya, Elena A. Kotova, Igor I. Agapov, Mikhail M. Moisenovich, Yuri N. Antonenko

Index: FEBS Lett. 588(9) , 1590-5, (2014)

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Abstract

• Unsaturated lipids protect gramicidin channels from photosensitized inactivation. • Photosensitizer binding to membrane is independent of lipid unsaturation. • Double bonds in lipids reduce gramicidin inactivation by tert-butyl hydroperoxide.